Basso, Laura and Boecking, Benjamin and Neff, Patrick and Brueggemann, Petra and Peters, Eva M. J. and Mazurek, Birgit (2022) Hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness and distress in chronic tinnitus. SCIENTIFIC REPORTS, 12 (1): 1934. ISSN 2045-2322,
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The role of stress and its neuroendocrine mediators in tinnitus is unclear. In this study, we measure cortisol as an indicator of hypothalamus-pituitary-adrenal (HPA) axis alterations and brain-derived neurotrophic factor (BDNF) as a marker of adaptive neuroplasticity in hair of chronic tinnitus patients to investigate relationships with tinnitus-related and psychological factors. Cross-sectional data from chronic tinnitus inpatients were analyzed. Data collection included hair sampling, pure tone audiometry, tinnitus pitch and loudness matching, and psychometric questionnaires. Elastic net regressions with n-fold cross-validation were performed for cortisol (N = 91) and BDNF (N = 87). For hair-cortisol (R-2 = 0.10), the strongest effects were sampling in autumn and body-mass index (BMI) (positive), followed by tinnitus loudness (positive) and smoking (negative). For hair-BDNF (R-2 = 0.28), the strongest effects were hearing aid use, shift work (positive), and tinnitus loudness (negative), followed by smoking, tinnitus-related distress (Tinnitus Questionnaire), number of experienced traumatic events (negative), and physical health-related quality of life (Short Form-12 Health Survey) (positive). These findings suggest that in chronic tinnitus patients, higher perceived tinnitus loudness is associated with higher hair-cortisol and lower hair-BDNF, and higher tinnitus-related distress with lower hair-BDNF. Regarding hair-BDNF, traumatic experiences appear to have additional stress-related effects, whereas hearing aid use and high physical health-related quality of life appear beneficial. Implications include the potential use of hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness or distress and the need for intensive future research into chronic stress-related HPA axis and neuroplasticity alterations in chronic tinnitus.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STRESS QUESTIONNAIRE PSQ; NEUROTROPHIC FACTOR BDNF; BRAIN; VALIDATION; DETERMINANTS; EXPRESSION; REGULARIZATION; DISORDERS; SALIVARY; ANXIETY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Feb 2024 16:22 |
| Last Modified: | 27 Feb 2024 16:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58141 |
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