Li, Huili and Herrmann, Thomas and Seessle, Jessica and Liebisch, Gerhard and Merle, Uta and Stremmel, Wolfgang and Chamulitrat, Walee (2022) Role of fatty acid transport protein 4 in metabolic tissues: insights into obesity and fatty liver disease. BIOSCIENCE REPORTS, 42 (6): BSR2021185. ISSN 0144-8463, 1573-4935
Full text not available from this repository. (Request a copy)Abstract
Fatty acid (FA) metabolism is a series of processes that provide structural substances, signalling molecules and energy. Ample evidence has shown that FA uptake is mediated by plasma membrane transporters including FA transport proteins (FATPs), caveolin-1, fatty-acid translocase (FAT)/CD36, and fatty-acid binding proteins. Unlike other FA transporters, the functions of FATPs have been controversial because they contain both motifs of FA transport and fatty acyl-CoA synthetase (ACS). The widely distributed FATP4 is not a direct FA transporter but plays a predominant function as an ACS. FATP4 deficiency causes ichthyosis premature syndrome in mice and humans associated with suppression of polar lipids but an increase in neutral lipids including triglycerides (TGs). Such a shift has been extensively characterized in enterocyte-, hepatocyte-, and adipocyte-specific Fatp4-deficient mice. The mutants under obese and non-obese fatty livers induced by different diets persistently show an increase in blood non-esterified free fatty acids and glycerol indicating the lipolysis of TGs. This review also focuses on FATP4 role on regulatory networks and factors that modulate FATP4 expression in metabolic tissues including intestine, liver, muscle, and adipose tissues. Metabolic disorders especially regarding blood lipids by FATP4 deficiency in different cell types are herein discussed. Our results may be applicable to not only patients with FATP4 mutations but also represent a model of dysregulated lipid homeostasis, thus providing mechanistic insights into obesity and development of fatty liver disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACYL-COA SYNTHETASE; ICHTHYOSIS PREMATURITY SYNDROME; INDUCED INSULIN-RESISTANCE; BAICALEIN 5,6,7-TRIMETHYL ETHER; ADIPOSE-TISSUE; PLASMA-MEMBRANE; NONALCOHOLIC STEATOHEPATITIS; GENOMIC REORGANIZATION; GENETIC POLYMORPHISMS; CHOLESTEROL UPTAKE |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 Sep 2023 09:39 |
| Last Modified: | 29 Feb 2024 15:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58145 |
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