Reiser, Elisabeth and Bazzano, Maria Victoria and Solano, Maria Emilia and Haybaeck, Johannes and Schatz, Christoph and Mangesius, Julian and Ganswindt, Ute and Toth, Bettina (2022) Unlaid Eggs: Ovarian Damage after Low-Dose Radiation. CELLS, 11 (7): 1219. ISSN 2073-4409
Full text not available from this repository.Abstract
The total body irradiation of lymphomas and co-irradiation in the treatment of adjacent solid tumors can lead to a reduced ovarian function, premature ovarian insufficiency, and menopause. A small number of studies has assessed the radiation-induced damage of primordial follicles in animal models and humans. Studies are emerging that evaluate radiation-induced damage to the surrounding ovarian tissue including stromal and immune cells. We reviewed basic laboratory work to assess the current state of knowledge and to establish an experimental setting for further studies in animals and humans. The experimental approaches were mostly performed using mouse models. Most studies relied on single doses as high as 1 Gy, which is considered to cause severe damage to the ovary. Changes in the ovarian reserve were related to the primordial follicle count, providing reproducible evidence that radiation with 1 Gy leads to a significant depletion. Radiation with 0.1 Gy mostly did not show an effect on the primordial follicles. Fewer data exist on the effects of radiation on the ovarian microenvironment including theca-interstitial, immune, endothelial, and smooth muscle cells. We concluded that a mouse model would provide the most reliable model to study the effects of low-dose radiation. Furthermore, both immunohistochemistry and fluorescence-activated cell sorting (FACS) analyses were valuable to analyze not only the germ cells but also the ovarian microenvironment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | low-dose radiation; ovarian damage; fertility preservation; mouse model; follicle count; oocyte |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 24 Apr 2025 09:54 |
| Last Modified: | 24 Apr 2025 09:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58186 |
Actions (login required)
 |
View Item |
