Staudt, Anna and Joerres, Rudolf A. and Hinterberger, Thilo and Lehnen, Nadine and Loew, Thomas and Budweiser, Stephan (2022) Associations of Post-Acute COVID syndrome with physiological and clinical measures 10 months after hospitalization in patients of the first wave. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 95. pp. 50-60. ISSN 0953-6205, 1879-0828
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Background: For a better understanding of the factors underlying the Post-Acute COVID Syndrome, we studied the relationship between symptoms and functional alterations in COVID-19 patients 10 months after hospitalization. Methods: One-hundred-one patients hospitalized between March 1st and June 30th 2020 participated in a follow-up visit for an assessment of clinical history, comorbidities, lung function, physical capacity and symptoms, including the SGRQ for health-related quality of life, PHQ-9-D for depression, and SOMS-2 J for somatoform disorders. Data were analyzed by univariate comparisons and multiple logistic regression analyses. Results: Median age was 60 years, 42% were female, 76% had at least one comorbidity, the median length of the hospital stay was 8 days, 19% had been on the ICU. The most prevalent symptoms included shortness of breath (49%), fatigue (49%) and cognitive impairment (39%). Signs of major depression (PHQ-9-D > 10) occurred in 28%/2% (p < 0.05) of patients with/without self-reported cognitive impairment, with median total SGRQ score being 25.4/5.3 (p < 0.05). There were associations between shortness of breath and BMI, SGRQ and hemoglobin levels; between fatigue, SGRQ and PHQ-9-D; and between cognitive impairment and PHQ-9-D (p < 0.05 each) but not with lung function or physical capacity. Characteristics of the acute disease were not related to symptoms. Conclusions: The findings demonstrate that 10 months after discharge from a hospital stay due to COVID-19, the percentages of patients with symptoms were high. Symptoms showed a consistent pattern but could not be attributed to altered lung function or physical capacity. Our results suggest a role for alternative etiologies including psychosocial factors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 6-MINUTE WALK; DEPRESSION; PHQ-9; COMORBIDITIES; SEVERITY; Post-Acute COVID Syndrome; Lung function; Symptoms; Depression; Somatization; HrQoL |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Medicine > Abteilung für Psychosomatische Medizin Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jan 2024 11:03 |
| Last Modified: | 26 Jan 2024 11:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58223 |
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