Piedade de Castro, Guilherme Assed and Ferreira Petean, Igor Bassi and Garcia de Paula-Silva, Francisco Wanderley and Kuchler, Erika Calvano and Antunes, Leonardo dos Santos and Bezerra Segato, Raquel Assed and Bezerra da Silva, Lea Assed and Correa, Silva-Sousa Alice and Sousa-Neto, Manoel Damiao (2023) Genetic polymorphism in the tumour necrosis factor alpha gene (G-308A) is associated with persistent apical periodontitis in Brazilians. INTERNATIONAL ENDODONTIC JOURNAL, 56 (1). pp. 17-26. ISSN 0143-2885, 1365-2591
Full text not available from this repository. (Request a copy)Abstract
Aim: To investigate if there was an association between genetic polymorphisms in tumour necrosis factor (TNF)-alpha and its receptors TNFRSF1A and TNFRSF1B with persistent apical periodontitis (PAP) in Brazilian subjects. Methodology: Patients who had pulpal necrosis and apical periodontitis at the time of treatment, with at least 1-year of follow-up after non-surgical root canal treatment were recalled. Three hundred and seventy eight subjects were included, 150 subjects with signs/symptoms of PAP and 228 subjects with root canal-treated teeth exhibiting healthy perirradicular tissues (healed). Genomic DNA was extracted from saliva and used for TNF-alpha (rs1800629), TNFRSF1A (rs1800693) and TNFRSF1B (rs1061622) genotyping by real-time PCR. Genotypes and alleles frequencies were evaluated by c2 or Fisher's exact tests and odds ratios were implemented (alpha = 5%). Results: The genetic polymorphism in TNF-alpha (rs1800629) was associated as a protective factor for the development of PAP (p < .05), once subjects who presented at least one allele A (AA+AG X GG), had a higher chance to lesion repair (p < .05). The polymorphisms rs1800693 and rs1061622 in TNF receptors (TNFRSF1A and TNFRSF1B, respectively) were not associated with the development of PAP (p > .05). Conclusions: The observed results demonstrate that polymorphism in TNF-alpha but not in its receptors is associated with PAP.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TNF-ALPHA; EXPRESSION; THERAPY; RISK; IL10; apical periodontitis; genetic polymorphisms; genetics; immune-inflammatory response; tumour necrosis factor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Mar 2024 10:44 |
| Last Modified: | 07 Mar 2024 10:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58239 |
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