Alves Antunes, Livia Azeredo and Moraes Pinheiro, Liz Helena and Castilho, Thuanny and Todoroff, Nicolle and Duarte, Camila and Tavares, Jhenyfer da Silva and Scariot, Rafaela and Kuechler, Erika Calvano and Antunes, Leonardo Santos (2022) Genetic polymorphisms in TNF-alpha as a potential biomarker for oral health-related quality of life in children. BRAZILIAN ORAL RESEARCH, 36: e059. ISSN 1807-3107,
Full text not available from this repository. (Request a copy)Abstract
This cross-sectional study aimed to assess if genetic polymorphisms in TNF-alpha are associated with a negative impact on Oral Health-Related Quality of Life (OHRQoL) in children with dental caries. A total of 307 pairs of parents/caregivers and children aged two to five years were selected. The children were clinically evaluated and classified according to caries experience and severity of active caries. The Brazilian Portuguese version of the Early Childhood Oral Health Impact Scale (ECOHIS) was used to assess OHRQoL. Genotyping analysis of genetic polymorphisms in TNF-alpha (rs1799724, rs1799964, and rs1800629) was performed using real-time polymerase chain reaction. In the recessive model, children with the CC genotype of TNF-alpha (rs1799964) had a significantly high chance of poor OHRQoL in the symptom domain (pain), in both the caries experience (p = 0.045) and the high-severity active caries phenotypes (p = 0.033) (Mann-Whitney U test). It was concluded that genetic polymorphisms in TNF-alpha are associated with OHRQoL related to the symptom domain (pain), suggesting that TNF-alpha could be used as a potential biomarker for OHRQoL. Understanding the genetic aspects associated with OHRQoL will allow the early identification of patients with OHRQoL disparities and provide personalized healthcare.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DENTAL-CARIES; BIOLOGICAL PATHWAYS; CANDIDATE GENES; ASSOCIATION; IMPACT; MARKERS; Genetics; Dental caries; Oral Health; Quality of Life |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Feb 2024 10:02 |
| Last Modified: | 02 Feb 2024 10:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58262 |
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