Moitinho-Silva, Lucas and Degenhardt, Frauke and Rodriguez, Elke and Emmert, Hila and Juzenas, Simonas and Mobus, Lena and Uellendahl-Werth, Florian and Sander, Nicole and Baurecht, Hansjorg and Tittmann, Lukas and Lieb, Wolfgang and Gieger, Christian and Peters, Annette and Ellinghaus, David and Bang, Corinna and Franke, Andre and Weidinger, Stephan and Ruehlemann, Malte Christoph (2022) Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota. NATURE COMMUNICATIONS, 13 (1): 6204. ISSN , 2041-1723
Full text not available from this repository. (Request a copy)Abstract
Despite the increasing knowledge about factors shaping the human microbiome, the host genetic factors that modulate the skin-microbiome interactions are still largely understudied. This contrasts with recent efforts to characterize host genes that influence the gut microbiota. Here, we investigated the effect of genetics on skin microbiota across three different skin microenvironments through meta-analyses of genome-wide association studies (GWAS) of two population-based German cohorts. We identified 23 genome-wide significant loci harboring 30 candidate genes involved in innate immune signaling, environmental sensing, cell differentiation, proliferation and fibroblast activity. However, no locus passed the strict threshold for study-wide significance (P<6.3x10(-10) for 80 features included in the analysis). Mendelian randomization (MR) analysis indicated the influence of staphylococci on eczema/dermatitis and suggested modulating effects of the microbiota on other skin diseases. Finally, transcriptional profiles of keratinocytes significantly changed after in vitro co-culturing with Staphylococcus epidermidis, chosen as a representative of skin commensals. Seven candidate genes from the GWAS were found overlapping with differential expression in the co-culturing experiments, warranting further research of the skin commensal and host genetic makeup interaction.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RNA; EXPRESSION; IDENTIFICATION; PROLIFERATION; METAANALYSIS; ACTIVATION; GC1QR/P33; MECHANISM; PROTEIN; RAF-1; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Feb 2024 06:58 |
| Last Modified: | 02 Feb 2024 06:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58283 |
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