Krenek, Tomas and Stich, Theresia and Docheva, Denitsa and Mikysek, Petr and Kostejn, Martin and Jandova, Vera and Fajgar, Radek and Pola, Michal and Kovarik, Tomas and Moskal, Denys and Forejtova, Jana and Pola, Josef (2022) Revisiting bioactivity of calcium titanate and titanium dioxide: Hydrolysis and complexation effects in osteogenic medium. SURFACE & COATINGS TECHNOLOGY, 447: 128820. ISSN 0257-8972, 1879-3347
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This study characterized laser-deposited CaTiO3 coats on several substrates by electron microscopy, X-ray diffraction, and Raman spectra. The hydrolytic stability of such coats exposed to ambient air and immersed into culture and osteogenic media has been respectively assessed by X-ray photoelectron spectra and energy dispersive X-ray analysis. It is shown these coats on titanium and micro/nanostructured oxidic titanium are not stable in air and culture or osteogenic media where they undergo hydrolysis and Ca leakage. The role of this hydrolysis is assessed and discussed in terms of not yet acknowledged complexation of the developing TiO(2 )surface with constituents of Dulbecco's Modified Eagle's medium. The effect of the deposited and additionally heated CT coatings on human mesenchymal stem cells is assessed regarding survival, proliferation and differentiation towards the osteogenic lineage in osteogenic medium. It is also stressed that the identified CaTiO3 hydrolysis in air and aquatic media seriously impacts the interpretation of bioactivity and physicochemical, catalytic and photocatalytic properties of CaTiO3 surfaces, which has not been yet admitted and led to erroneous conclusions in many previous studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TIO2 NANOTUBES; SURFACE MODIFICATION; CATIO3; PEROVSKITE; DIFFERENTIATION; COATINGS; FILM; BIOFUNCTIONALIZATION; NANOTOPOGRAPHY; DISSOLUTION; Calcium titanate coat; Hydrolysis; Micro/nanostructured oxidic titanium; hMSCs; Osteogenic differentiation; DMEM-TiO(2 )interactions; Self-organized precipitation of DMEM |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jan 2024 13:43 |
| Last Modified: | 26 Jan 2024 13:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58284 |
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