Fenk, Sabine and Fischer, Marcus and Strack, Christina and Schmitz, Gerd and Loew, Thomas and Lahmann, Claas and Baessler, Andrea (2015) Successful Weight Reduction Improves Left Ventricular Diastolic Function and Physical Performance in Severe Obesity. INTERNATIONAL HEART JOURNAL, 56 (2). pp. 196-202. ISSN 1349-2365, 1349-3299
Full text not available from this repository. (Request a copy)Abstract
Obesity and the metabolic syndrome (MetS) are risk factors for left ventricular diastolic dysfunction (LVDD). However, little is known about the impact of successful weight reduction (WR) on diastolic function and physical performance. Obese subjects (empty setBMI 40.2 +/- 8.6 kg/m(2)) underwent a 1-year WR program comprising diet and lifestyle components. Echocardiography and exercise capacity (6-minute walk) were performed at baseline and after 1 year. The distribution of weight reduction was split at the sample median and subjects were dichotomized in "successful WR" (% WR >= median, corresponding to a weight loss of 8%) and "failed-WIZ" (% WR < median). From a total of 188 obese subjects, 71 had LVDD at baseline. Obese patients with successful WR improved their MetS alterations, including fasting glucose, insulin, lipids, adipokines, blood pressure levels, and epicardial fat thickness. The same was not true for obesity with failed WR. Subjects with successful WR demonstrated significant improvement in echocardiographic LVDD parameters (median [interquartile range]): Delta e' (2,5 [-1.0, 4.7], P < 0.01), Delta e'/a' (0.34 [0.07, 079], P < 0.01), Delta E/e' (-1.14 [-2.72, -0.54], P < 0.05), Delta E/A (0.08 [-0.04, 0.26], P < 0.05), Delta Ard-Ad (-28 [-54, -4], P < 0.01), and 6-minute walk distance (65 [19, 135], P < 0.01). Improvement of >= 2 LVDD criteria was accomplished in 30% of subjects with WR versus 10% without (P = 0.009). Using multivariable regression analysis, reduction of epicardial fat thickness was particularly predictive for the improvement of diastolic function. In summary, in severe obesity, successful long-term WR was associated with improved LV diastolic function and exercise capacity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NORMAL EJECTION FRACTION; BODY-MASS-INDEX; HEART-FAILURE; RISK-FACTORS; MORBID-OBESITY; DISEASE; ECHOCARDIOGRAPHY; DYSFUNCTION; PREVALENCE; MORTALITY; Adiposity; Metabolic syndrome; Diastolic dysfunction; Weight loss |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Jul 2019 10:45 |
| Last Modified: | 24 Jul 2019 10:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5830 |
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