Klimek, L. and Hagemann, J. and Welkoborsky, H. J. and Cuevas, M. and Casper, I and Foerster-Ruhrmann, U. and Klimek, F. and Hintschich, C. A. and Huppertz, T. and Bergmann, C. and Tomazic, P. and Becker, S. (2022) Epitheliale Immunregulation entzündlicher Atemwegserkrankungen am Beispiel der Chronischen Rhinosinusitis (CRS). Allergologie select, 6. pp. 148-166. ISSN 0344-5062
Full text not available from this repository. (Request a copy)Abstract
Background: The epithelial immune regulation is an essential and protective feature of the barrier function in the area of the mucous membranes of the airways. Damage to the epithelial barrier can result in chronic inflammatory diseases, such as chronic rhino sinusitis (CRS) or bronchial asthma. The thymic stromal lymphopoietin (TSLP) is a central regulator in the epithelial barrier function and is associated with type 2 and non-type 2 and guideline registers and the Cochrane Library. Human studies or studies on human cells that were published between 2010 and 2020 and in which the immune mechanisms of TSLP in type 2 and non-type 2 inflammation were examined were considered. Result: TSLP is an epithelial cytokine (alarmin) and a central regulator of the immune reaction, especially in the case of chronic airway inflammation. Induction of TSLP is implicated in the pathogenesis of many diseases like CRS and triggers a cascade of subsequent inflammatory reactions. Conclusion: Treatment with TSLP-blocking monoclonal antibodies could therefore open up interesting therapeutic options. The long-term safety and effectiveness of TSLP blockade has yet to be investigated.
| Item Type: | Article |
|---|---|
| Additional Information: | Jg. und Seitenzählung habe ich vom pdf korrigiert /gup |
| Uncontrolled Keywords: | THYMIC STROMAL LYMPHOPOIETIN; INNATE LYMPHOID-CELLS; GENOME-WIDE ASSOCIATION; DENDRITIC CELLS; SEVERE ASTHMA; ALLERGIC-ASTHMA; GERMAN SOCIETY; ENVIRONMENTAL MEDICINE; INCREASED EXPRESSION; CLINICAL IMMUNOLOGY; alarmine; CRS; CRSwNP; epithelial immune regu-lation; T2-inflammation; Tezepelumab; TSLP |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 May 2024 07:47 |
| Last Modified: | 16 May 2024 07:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58303 |
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