Mauschitz, Matthias M. and Schmitz, Marie-Therese and Verzijden, Timo and Schmid, Matthias and Thee, Eric F. and Colijn, Johanna M. and Delcourt, Cecile and Cougnard-Gregoire, Audrey and Merle, Benedicte M. J. and Korobelnik, Jean-Francois and Gopinath, Bamini and Mitchell, Paul and Elbaz, Hisham and Schuster, Alexander K. and Wild, Philipp S. and Brandl, Caroline and Stark, Klaus J. and Heid, Iris M. and Günther, Felix and Peters, Annette and Klaver, Caroline C. W. and Finger, Robert P. (2022) Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study. AMERICAN JOURNAL OF OPHTHALMOLOGY, 236. pp. 99-106. ISSN 0002-9394, 1879-1891
Full text not available from this repository. (Request a copy)Abstract
PURPOSE: To investigate the impact of physical activity (PA) on the incidence or progression of age-related macular degeneration (AMD) in the general population. DESIGN: Meta-analysis of longitudinal cohort studies. METHODS: We included 14,630 adults with no or early AMD at baseline from 7 population-based studies and examined associations of PA with AMD incidence and progression using multistate models (MSM) per study and subsequent random effects meta-analysis. Age effects were assessed using meta-regression. The main outcome measure was the hazard ratio (HR) for incident early or progression to late AMD. RESULTS: At baseline, mean age was 60.7 +/- 6.9 to 76.4 +/- 4.3 years, and prevalence of early AMD was 7.7% (range, 3.6%-16.9%) between cohorts. During followup, 1461 and 189 events occurred for early and late AMD, respectively. In meta-analyses, no or low to moderate PA (high PA as reference) was associated with an increased risk for incident early AMD (HR, 1.19; 95% CI, 1.01-1.40; P = .04), but not for late AMD. In subsequent meta-regression, we found no association of age with the effect of PA on incident AMD. CONCLUSIONS: Our study suggests high levels of PA to be protective for the development of early AMD across several population-based cohort studies. Our results establish PA as a modifiable risk factor for AMD and inform further AMD prevention strategies to reduce its public health impact. (C) 2021 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OXIDATIVE STRESS; PREVALENCE; CLASSIFICATION; MACULOPATHY; DIETARY |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jan 2024 14:31 |
| Last Modified: | 26 Jan 2024 14:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58313 |
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