Sikic, Danijel and Eckstein, Markus and Weyerer, Veronika and Kubon, Jennifer and Breyer, Johannes and Roghmann, Florian and Kunath, Frank and Keck, Bastian and Erben, Philipp and Hartmann, Arndt and Wirtz, Ralph M. and Wullich, Bernd and Taubert, Helge and Wach, Sven (2022) High expression of ERBB2 is an independent risk factor for reduced recurrence-free survival in patients with stage T1 non-muscle-invasive bladder cancer. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 40 (2): 63.e9. ISSN 1078-1439, 1873-2496
Full text not available from this repository. (Request a copy)Abstract
Introduction: Molecular markers associated with breast cancer are assumed to be associated with outcome in non-muscle-invasive bladder cancer (NMIBC). Materials and methods: We retrospectively investigated the association of the mRNA expression of estrogen receptor 1 (ESR1) and 2 (ESR2), progesterone receptor (PGR), MKI67, and HER2 (ERBB2) with recurrence-free (RFS), cancer-specific (CSS), and overall survival (OS) in 80 patients with stage T1 NMIBC. Results: High expression of ESR2 (P = 0.003), ERBB2 (P < 0.001), and MKI67 (P = 0.029) was associated with shorter RFS. Only high ERBB2 was an independent prognostic factor for reduced RFS (HR = 2.98; P = 0.009). When sub stratifying the cohort, high ESR2 was associated with reduced RFS (P < 0.001), CSS (P = 0.037) and OS (P = 0.006) in patients without instillation therapy. High ESR2 was associated with reduced CSS (P = 0.018) and OS (P = 0.029) in females and with shorter RFS in both sexes (males: P = 0.035; females: P = 0.010). Patients with high ERBB2 showed reduced CSS (P = 0.011) and OS (P = 0.042) in females and reduced CSS (P = 0.012) in those without instillation, while RFS was significantly reduced irrespective of sex or instillation. Conclusion: High mRNA expression of ERBB2 is an independent predictor of reduced RFS in patients with stage T1 NMIBC. High ERBB2 and ESR2 are associated with reduced outcomes, especially in females and patients without instillation therapy. (C) 2021 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ESTROGEN-RECEPTOR-BETA; MESSENGER-RNA EXPRESSION; TRANSITIONAL-CELL CARCINOMA; GROWTH-FACTOR RECEPTOR; UROTHELIAL CARCINOMA; PROGNOSTIC-SIGNIFICANCE; GENE AMPLIFICATION; MOLECULAR TAXONOMY; URINARY-BLADDER; BREAST-CANCER; Non-muscle-invasive bladder cancer; ERBB2; Estrogen receptor; HER2; Urothelial carcinoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jan 2024 14:33 |
| Last Modified: | 29 Jan 2024 13:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58343 |
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