Cuvelier, Geoffrey D. E. and Schoettler, Michelle and Buxbaum, Nataliya P. and Pinal-Fernandez, Iago and Schmalzing, Marc and Distler, Joerg H. W. and Penack, Olaf and Santomasso, Bianca D. and Zeiser, Robert and Angstwurm, Klemens and MacDonald, Kelli P. A. and Kimberly, W. Taylor and Taylor, Naomi and Bilic, Ervina and Banas, Bernhard and Buettner-Herold, Maike and Sinha, Namita and Greinix, Hildegard T. and Pidala, Joseph and Schultz, Kirk R. and Williams, Kirsten M. and Inamoto, Yoshihiro and Cutler, Corey and Griffith, Linda M. and Lee, Stephanie J. and Sarantopoulos, Stefanie and Pavletic, Steven Z. and Wolff, Daniel (2022) Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force. TRANSPLANTATION AND CELLULAR THERAPY, 28 (8). pp. 426-445. ISSN 2666-6375, 2666-6367
Full text not available from this repository. (Request a copy)Abstract
Alloreactive and autoimmune responses after allogeneic hematopoietic cell transplantation can occur in nonclas-sical chronic graft-versus-host disease (chronic GVHD) tissues and organ systems or manifest in atypical ways in classical organs commonly affected by chronic GVHD. The National Institutes of Health (NIH) consensus projects were developed to improve understanding and classification of the clinical features and diagnostic criteria for chronic GVHD. Although still speculative whether atypical manifestations are entirely due to chronic GVHD, these manifestations remain poorly captured by the current NIH consensus project criteria. Examples include chronic GVHD impacting the hematopoietic system as immune mediated cytopenias, endothelial dysfunction, or as atypi-cal features in the musculoskeletal system, central and peripheral nervous system, kidneys, and serous mem-branes. These purported chronic GVHD features may contribute significantly to patient morbidity and mortality. Most of the atypical chronic GVHD features have received little study, particularly within multi-institutional and prospective studies, limiting our understanding of their frequency, pathogenesis, and relation to chronic GVHD. This NIH consensus project task force report provides an update on what is known and not known about the atyp-ical manifestations of chronic GVHD while outlining a research framework for future studies to be undertaken within the next 3 to 7 years. We also provide provisional diagnostic criteria for each atypical manifestation, along with practical investigation strategies for clinicians managing patients with atypical chronic GVHD features. (c) 2022 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; AUTOIMMUNE HEMOLYTIC-ANEMIA; CENTRAL-NERVOUS-SYSTEM; BONE-MARROW-TRANSPLANTATION; CORD BLOOD TRANSPLANTATION; TUBULAR BRUSH-BORDER; CD4(+) T-CELLS; CHRONIC GVHD; THROMBOTIC MICROANGIOPATHY; NEUROLOGIC COMPLICATIONS; Chronic graft-versus-host disease; Atypical; National Institutes of Health Consensus Project Task Force |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Abteilung für Nephrologie Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jan 2024 14:25 |
| Last Modified: | 29 Jan 2024 13:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58390 |
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