Banerjee, Pratiti and Veuskens, Bert and Goicoechea de Jorge, Elena and Jozsi, Mihaly and Baeumner, Antje J. and Steiner, Mark-Steven and Pouw, Richard B. and Toonen, Erik J. M. and Pauly, Diana and Poppelaars, Felix (2022) Evaluating the clinical utility of measuring levels of factor H and the related proteins. MOLECULAR IMMUNOLOGY, 151. pp. 166-182. ISSN 0161-5890, 1872-9142
Full text not available from this repository. (Request a copy)Abstract
After years of disappointing clinical results, the tide has finally changed and complement targeted-therapies have become a validated and accepted treatment option for several diseases. These accomplishments have revitalized the field and brought renewed attention to the prospects that complement therapeutics can offer. Streamlining diagnostics and therapeutics is imperative in this new era of clinical use of complement therapeutics. However, the incredible success in therapeutics has not been accompanied by the development of novel standardized tools for complement testing. Complement biomarkers can assist in the risk assessment and diagnosis of diseases as well as the prediction of disease progression and treatment response. Recently, a group of complement proteins has been suggested to be highly relevant in various complement-associated disorders, namely the human factor H (FH) protein family. This family of closely related proteins consists of FH, FH-like protein 1, and five factor H -related proteins, and they have been linked to eye, kidney, infectious, vascular, and autoimmune diseases as well as cancer. The goal of this review is to provide a comprehensive overview of the available data on circulating levels of FH and its related proteins in different pathologies. In addition, we examined the current literature to determine the clinical utility of measuring levels of the FH protein family in health and disease. Finally, we discuss future steps that are needed to make their clinical translation a reality.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COMPLEMENT FACTOR-H; HEMOLYTIC-UREMIC SYNDROME; C-REACTIVE PROTEIN; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; GENOME-WIDE ASSOCIATION; MACULAR DEGENERATION; MENINGOCOCCAL DISEASE; MONOCLONAL-ANTIBODIES; INHIBITOR ECULIZUMAB; IGA NEPHROPATHY; Complement system; Factor H; FHR; FHL-1; Biomarker |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Antje J. Bäumner, formerly Prof. Wolfbeis) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 06:01 |
| Last Modified: | 30 Jan 2024 06:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58407 |
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