Mader, Marius Marc-Daniel and Deuter, Daniel and Sauvigny, Thomas and Borchert, Patrick and Faizy, Tobias D. and Bester, Maxim and Westphal, Manfred and Rosengarth, Katharina and Schmidt, Nils O. and Sedlacik, Jan and Duehrsen, Lasse (2022) Diffusion tensor imaging changes in patients with glioma-associated seizures. JOURNAL OF NEURO-ONCOLOGY, 160 (2). pp. 311-320. ISSN 0167-594X, 1573-7373
Full text not available from this repository. (Request a copy)Abstract
Introduction Structural white matter changes associated with certain epilepsy subtypes have been demonstrated using diffusion tensor imaging (DTI). This observational study aims to identify potential water diffusion abnormalities in glioma patients with associated seizures. Methods Two cohorts from two centers were analyzed independently: (A) Prospectively recruited patients diagnosed with glioma who received preoperative DTI to measure mean diffusivity (MD) and fractional anisotropy (FA) in regions-of-interest (ROIs) including the marginal tumor zone (TU), adjacent peritumoral white matter as well as distant ipsilateral and contralateral white matter and cortex. Data were compared between patients with and without seizures and tested for statistical significance. (B) A retrospective cohort using an alternative technical approach sampling ROIs in contrast enhancement, necrosis, non-enhancing tumor, marginal non-enhancing tumor zone, peritumoral tissue, edema and non-tumorous tissue. Results (A) The prospective study cohort consisted of 23 patients with 12 (52.2%) presenting with a history of seizures. There were no significant seizure-associated differences in MD or FA for non-tumor white matter or cortical areas. MD-TU was significantly lower in patients with seizures (p = 0.005). (B) In the retrospective cohort consisting of 46 patients with a seizure incidence of 50.0%, significantly decreased normalized values of MD were observed for non-enhancing tumor regions of non-glioblastoma multiforme (GBM) cases in patients with seizures (p = 0.022). Conclusion DTI analyses in glioma patients demonstrated seizure-associated diffusion restrictions in certain tumor-related areas. No other structural abnormalities in adjacent or distant white matter or cortical regions were detected.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | WHITE-MATTER ABNORMALITIES; LOW-GRADE GLIOMA; EX-VIVO; ROBUST; IDH1; EPILEPSY; OPTIMIZATION; REGISTRATION; MUTATIONS; ACCURATE; Glioma; Seizures; Diffusion Tensor Imaging; Humans; White Matter; Epilepsy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2024 12:44 |
| Last Modified: | 01 Feb 2024 12:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58418 |
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