Tap, Lisanne and Corsonello, Andrea and Di Rosa, Mirko and Fabbietti, Paolo and Formiga, Francesc and Moreno-Gonzalez, Rafael and Arnlov, Johan and Carlsson, Axel C. and Polinder-Bos, Harmke A. and Roller-Wirnsberger, Regina E. and Wirnsberger, Gerhard H. and Kostka, Tomasz and Guligowska, Agnieszka and Artzi-Medvedik, Rada and Yehoshua, Ilan and Weingart, Christian and Sieber, Cornel C. and Gil, Pedro and Lainez Martinez, Sara and Lattanzio, Fabrizia and Mattace-Raso, Francesco U. S. (2022) Inflammaging and Blood Pressure Profiles in Late Life: The Screening for CKD among Older People across Europe (SCOPE) Study. JOURNAL OF CLINICAL MEDICINE, 11 (24): 7311. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
The neutrophil-to-lymphocyte ratio (NLR) is a marker for systemic inflammation. Since inflammation plays a relevant role in vascular aging, the aim of this study was to investigate whether NLR is associated with blood pressure profiles in older adults. This study was performed within the framework of the SCOPE study including 2461 outpatients aged 75 years and over. Mean blood pressure values, namely systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) were investigated across tertiles of NLR. Change in blood pressure levels in 2 years of follow-up were compared across categories of baseline NLR. Data of 2397 individuals were used, of which 1854 individuals had hypertension. Mean values of blood pressure did not differ across categories of baseline NLR in individuals without hypertension. Individuals with hypertension with a high-range NLR had lower SBP and PP when compared to those in low-range NLR (mean difference SBP -2.94 mmHg, p = 0.032 and PP -2.55 mmHg, p = 0.030). Mean change in blood pressure in 2 years did only slightly differ in non-clinically relevant ranges, when compared across tertiles of baseline NLR. NLR as a marker of inflammaging was not associated with unfavorable blood pressure profiles in older individuals with or without hypertension.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TO-LYMPHOCYTE RATIO; C-REACTIVE PROTEIN; ARTERIAL STIFFNESS; BLOCKERS; ADULTS; inflammation; neutrophil-to-lymphocyte ratio; hypertension; blood pressure; vascular aging; older adults |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2024 12:25 |
| Last Modified: | 01 Feb 2024 12:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58431 |
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