Singh, Jeeshan and Herrmann, Irmgard and Mahajan, Aparna and Schauer, Christine and Shan, Xiaomei and Hartmann, Arndt and Rieker, Ralf J. and Evert, Katja and Falkeis, Christina and Naschberger, Elisabeth and von Stillfried, Saskia and Boor, Peter and Munoz, Luis E. and Schett, Georg and Herrmann, Martin and Knopf, Jasmin (2022) A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (23): 15126. ISSN 1661-6596, 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Vascular occlusions in patients with coronavirus diseases 2019 (COVID-19) have been frequently reported in severe outcomes mainly due to a dysregulation of neutrophils mediating neutrophil extracellular trap (NET) formation. Lung specimens from patients with COVID-19 have previously shown a dynamic morphology, categorized into three types of pleomorphic occurrence based on histological findings in this study. These vascular occlusions in lung specimens were also detected using native endogenous fluorescence or NEF in a label-free method. The three types of vascular occlusions exhibit morphology of DNA rich neutrophil elastase (NE) poor (type I), NE rich DNA poor (type II), and DNA and NE rich (type III) cohort of eleven patients with six males and five females. Age and gender have been presented in this study as influencing variables linking the occurrence of several occlusions with pleomorphic contents within a patient specimen and amongst them. This study reports the categorization of pleomorphic occlusions in patients with COVID-19 and the detection of these occlusions in a label-free method utilizing NEF.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEUTROPHIL; AGE; SARS-CoV-2; COVID-19; immunothrombosis; occlusions; pleomorphism; native endogenous fluorescence; age; gender |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2024 08:00 |
| Last Modified: | 01 Feb 2024 08:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58474 |
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