Mauschitz, Matthias M. and Verzijden, Timo and Schuster, Alexander K. and Elbaz, Hisham and Pfeiffer, Norbert and Khawaja, Anthony and Luben, Robert N. and Foster, Paul J. and Rauscher, Franziska G. and Wirkner, Kerstin and Kirsten, Toralf and Jonas, Jost B. and Bikbov, Mukharram M. and Hogg, Ruth and Peto, Tunde and Cougnard-Gregoire, Audrey and Bertelsen, Geir and Erke, Maja Gran and Topouzis, Fotis and Giannoulis, Dimitrios A. and Brandl, Caroline and Heid, Iris M. and Creuzot-Garcher, Catherine P. and Gabrielle, Pierre-Henry and Hense, Hans-Werner and Pauleikhoff, Daniel and Barreto, Patricia and Coimbra, Rita and Piermarocchi, Stefano and Daien, Vincent and Holz, Frank G. and Delcourt, Cecile and Finger, Robert P. (2023) Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans. BRITISH JOURNAL OF OPHTHALMOLOGY, 107 (12). pp. 1880-1886. ISSN 0007-1161, 1468-2079
Full text not available from this repository. (Request a copy)Abstract
Background/aimsTo investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. MethodsWe included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis. ResultsBetween studies, mean age ranged from 61.5 +/- 7.1 to 82.6 +/- 3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and late AMD, respectively. In the meta-analysis of fully adjusted multivariable models, lipid-lowering drugs (LLD) and antidiabetic drugs were associated with lower prevalent any AMD (OR 0.85, 95% CI=0.79 to 0.91 and OR 0.78, 95% CI=0.66 to 0.91). We found no association with late AMD or with any other medication. ConclusionOur study indicates a potential beneficial effect of LLD and antidiabetic drug use on prevalence of AMD across multiple European cohorts. Our findings support the importance of metabolic processes in the multifactorial aetiology of AMD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STATIN USE; PHYSICAL-ACTIVITY; PROGRESSION; RISK; METFORMIN; CHOLESTEROL; PREVALENCE; INHIBITORS; HEALTH; EYE; drugs; epidemiology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 09 Jan 2025 10:18 |
| Last Modified: | 09 Jan 2025 10:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58497 |
Actions (login required)
 |
View Item |
