Netto, Jeffrey and Teren, Andrej and Burkhardt, Ralph and Willenberg, Anja and Beutner, Frank and Henger, Sylvia and Schuler, Gerhard and Thiele, Holger and Isermann, Berend and Thiery, Joachim and Scholz, Markus and Kaiser, Thorsten (2022) Biomarkers for Non-Invasive Stratification of Coronary Artery Disease and Prognostic Impact on Long-Term Survival in Patients with Stable Coronary Heart Disease. NUTRIENTS, 14 (16): 3433. ISSN , 2072-6643
Full text not available from this repository. (Request a copy)Abstract
Knowledge about cardiac and inflammatory biomarkers in patients with stable coronary artery disease (CAD) is limited. To address this, we analyzed 3072 patients (36% female) with a median follow-up of 10 years in the Leipzig LIFE Heart Study with suspected CAD with coronary angiography. Selected biomarkers included troponin T (hsTNT), N-terminal pro B-type natriuretic peptide (NT-proBNP), copeptin, C-reactive protein (hsCRP), and interleukin-6 (IL-6). Patients were stratified by CAD severity: CAD0 (no sclerosis), CAD1 (non-obstructive, i.e., stenosis < 50%), and CAD2 (>= one stenosis >= 50%). Group comparison (GC) included GC1: CAD0 + 1 vs. CAD2; GC2: CAD0 vs. CAD1 + 2. CAD0, CAD1, and CAD2 were apparent in 1271, 631, and 1170 patients, respectively. Adjusted for classical risk factors, hs-cTnT, NT-proBNP, and IL-6 differed significantly in both GC and hsCRP only in GC2. After multivariate analysis, hs-cTnT, NT-proBNP, and IL-6 remained significant in GC1. In GC2, hs-cTnT (p < 0.001) and copeptin (p = 0.014) reached significance. Ten-year survival in groups CAD0, CAD1, and CAD2 was 88.3%, 77.3%, and 72.4%. Incorporation of hs-cTnT, NT-proBNP, copeptin, and IL-6 improved risk prediction (p < 0.001). The studied cardiac and inflammatory biomarkers enable fast and precise non-invasive identification of mortality risk in CAD patients, allowing the tailoring of primary and secondary CAD prevention.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SENSITIVITY CARDIAC TROPONIN; INFLAMMATION; ASSOCIATION; MORTALITY; COPEPTIN; RISK; biomarkers; stable coronary artery disease (CAD); troponin T; long-term survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2024 07:38 |
| Last Modified: | 01 Feb 2024 07:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58500 |
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