Schuster, Sebastian and Beyer, Leonie and Palleis, Carla and Harris, Stefanie and Schmitt, Julia and Weidinger, Endy and Prix, Catharina and Boetzel, Kai and Danek, Adrian and Rauchmann, Boris-Stephan and Stoecklein, Sophia and Lindner, Simon and Unterrainer, Marcus and Albert, Nathalie L. and Mittlmeier, Lena M. and Wetzel, Christian and Rupprecht, Rainer and Rominger, Axel and Bartenstein, Peter and Perneczky, Robert and Levin, Johannes and Hoeglinger, Guenter U. and Brendel, Matthias and Dekorsy, Franziska J. (2022) Impact of Partial Volume Correction on [F-18]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome. BRAIN SCIENCES, 12 (2): 204. ISSN , 2076-3425
Full text not available from this repository. (Request a copy)Abstract
Corticobasal syndrome (CBS) is a rare neurodegenerative condition characterized by four-repeat tau aggregation in the cortical and subcortical brain regions and accompanied by severe atrophy. The aim of this study was to evaluate partial volume effect correction (PVEC) in patients with CBS compared to a control cohort imaged with the 18-kDa translocator protein (TSPO) positron emission tomography (PET) tracer [F-18]GE-180. Eighteen patients with CBS and 12 age- and sex-matched healthy controls underwent [F-18]GE-180 PET. The cortical and subcortical regions were delineated by deep nuclei parcellation (DNP) of a 3D-T1 MRI. Region-specific subcortical volumes and standardized uptake values and ratios (SUV and SUVr) were extracted before and after region-based voxel-wise PVEC. Regional volumes were compared between patients with CBS and controls. The % group differences and effect sizes (CBS vs. controls) of uncorrected and PVE-corrected SUVr data were compared. Single-region positivity in patients with CBS was assessed by a >2 SD threshold vs. controls and compared between uncorrected and PVE-corrected data. Smaller regional volumes were detected in patients with CBS compared to controls in the right ventral striatum (p = 0.041), the left putamen (p = 0.005), the right putamen (p = 0.038) and the left pallidum (p = 0.015). After applying PVEC, the % group differences were distinctly higher, but the effect sizes of TSPO uptake were only slightly stronger due to the higher variance after PVEC. The single-region positivity of TSPO PET increased in patients with CBS after PVEC (100 vs. 83 regions). PVEC in the cortical and subcortical regions is valuable for TSPO imaging of patients with CBS, leading to the improved detection of elevated [F-18]GE-180 uptake, although the effect sizes in the comparison against the controls did not improve strongly.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TAU PATHOLOGY; AMYLOID PET; DEGENERATION; DISEASE; NEUROINFLAMMATION; HYPOMETABOLISM; ACTIVATION; PHENOTYPES; SIGNATURES; PATTERNS; corticobasal syndrome; partial volume effect; positron emission tomography; TSPO PET; [F-18]GE-180; subcortical atrophy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2024 07:32 |
| Last Modified: | 01 Feb 2024 07:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58517 |
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