Tabak, Benjamin A. and Leng, Gareth and Szeto, Angela and Parker, Karen J. and Verbalis, Joseph G. and Ziegler, Toni E. and Lee, Mary R. and Neumann, Inga D. and Mendez, Armando J. (2023) Advances in human oxytocin measurement: challenges and proposed solutions. MOLECULAR PSYCHIATRY, 28 (1). pp. 127-140. ISSN 1359-4184, 1476-5578
Full text not available from this repository. (Request a copy)Abstract
Oxytocin, a neuropeptide known for its role in reproduction and socioemotional processes, may hold promise as a therapeutic agent in treating social impairments in patient populations. However, research has yet to uncover precisely how to manipulate this system for clinical benefit. Moreover, inconsistent use of standardized and validated oxytocin measurement methodologies-including the design and study of hormone secretion and biochemical assays-present unresolved challenges. Human studies measuring peripheral (i.e., in plasma, saliva, or urine) or central (i.e., in cerebrospinal fluid) oxytocin concentrations have involved very diverse methods, including the use of different assay techniques, further compounding this problem. In the present review, we describe the scientific value in measuring human endogenous oxytocin concentrations, common issues in biochemical analysis and study design that researchers face when doing so, and our recommendations for improving studies using valid and reliable methodologies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BIOANALYTICAL METHOD VALIDATION; PLASMA OXYTOCIN; INTRANASAL OXYTOCIN; PERIPHERAL OXYTOCIN; URINARY OXYTOCIN; CEREBROSPINAL-FLUID; ENDOGENOUS OXYTOCIN; PSYCHIATRIC-DISORDERS; AFFILIATIVE BEHAVIOR; PSYCHOSOCIAL STRESS |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Feb 2024 07:08 |
| Last Modified: | 21 Feb 2024 07:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58522 |
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