Brozat, Jonathan F. and Hanses, Frank and Haelberger, Martina and Stecher, Melanie and Dreher, Michael and Tometten, Lukas and Ruethrich, Maria M. and Vehreschild, Janne J. and Trautwein, Christian and Borgmann, Stefan and Vehreschild, Maria J. G. T. and Jakob, Carolin E. M. and Stallmach, Andreas and Wille, Kai and Hellwig, Kerstin and Isberner, Nora and Reuken, Philipp A. and Geisler, Fabian and Nattermann, Jacob and Bruns, Tony (2022) COVID-19 mortality in cirrhosis is determined by cirrhosis-associated comorbidities and extrahepatic organ failure: Results from the multinational LEOSS registry. UNITED EUROPEAN GASTROENTEROLOGY JOURNAL, 10 (4). pp. 409-424. ISSN 2050-6406, 2050-6414
Full text not available from this repository. (Request a copy)Abstract
Background and Objective International registries have reported high mortality rates in patients with liver disease and COVID-19. However, the extent to which comorbidities contribute to excess COVID-19 mortality in cirrhosis is controversial. Methods We used the multinational Lean European Open Survey on SARS-CoV-2-infected patients (LEOSS) to identify patients with cirrhosis documented between March 2020 and March 2021, when the wild-type and alpha variant were predominant. We compared symptoms, disease progression and mortality after propensity score matching (PSM) for age, sex, obesity, smoking status, and concomitant diseases. Mortality was also compared with that of patients with spontaneous bacterial peritonitis (SBP) without SARS-CoV-2 infection, a common bacterial infection and well-described precipitator of acute-on-chronic liver failure. Results Among 7096 patients with SARS-CoV-2 infection eligible for analysis, 70 (0.99%) had cirrhosis, and all were hospitalized. Risk factors for severe COVID-19, such as diabetes, renal disease, and cardiovascular disease were more frequent in patients with cirrhosis. Case fatality rate in patients with cirrhosis was 31.4% with the highest odds of death in patients older than 65 years (43.6% mortality; odds ratio [OR] 4.02; p = 0.018), Child-Pugh class C (57.1%; OR 4.00; p = 0.026), and failure of two or more organs (81.8%; OR 19.93; p = 0.001). After PSM for demographics and comorbidity, the COVID-19 case fatality of patients with cirrhosis did not significantly differ from that of matched patients without cirrhosis (28.8% vs. 26.1%; p = 0.644) and was similar to the 28-day mortality in a comparison group of patients with cirrhosis and SBP (33.3% vs. 31.5%; p = 1.000). Conclusions In immunologically naive patients with cirrhosis, mortality from wild-type SARS-CoV-2 and the alpha variant is high and is largely determined by cirrhosis-associated comorbidities and extrahepatic organ failure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC LIVER-FAILURE; DECOMPENSATED CIRRHOSIS; OUTCOMES; INFECTIONS; ACLD; chronic liver disease; cirrhosis; COVID-19; SARS-CoV-2; SBP |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Notfallambulanz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2024 07:16 |
| Last Modified: | 01 Feb 2024 07:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58535 |
Actions (login required)
 |
View Item |
