Ziemann, Malte and Suwelack, Barbara and Banas, Bernhard and Budde, Klemens and Einecke, Gunilla and Hauser, Ingeborg and Heinemann, Falko Markus and Kauke, Teresa and Kelsch, Reinhard and Koch, Martina and Lachmann, Nils and Reuter, Stefan and Seidl, Christian and Sester, Urban and Zecher, Daniel (2022) Determination of unacceptable HLA antigen mismatches in kidney transplant recipients. HLA, 100 (1). pp. 3-17. ISSN 2059-2302, 2059-2310
Full text not available from this repository. (Request a copy)Abstract
With the introduction of the virtual allocation crossmatch in the Eurotransplant (ET) region in 2023, the determination of unacceptable antigen mismatches (UAM) in kidney transplant recipients is of utmost importance for histocompatibility laboratories and transplant centers. Therefore, a joined working group of members from the German Society for Immunogenetics (Deutsche Gesellschaft fur Immungenetik, DGI) and the German Transplantation Society (Deutsche Transplantationsgesellschaft, DTG) revised and updated the previous recommendations from 2015 in light of recently published evidence. Like in the previous version, a wide range of topics is covered from technical issues to clinical risk factors. This review summarizes the evidence about the prognostic value of contemporary methods for HLA antibody detection and identification, as well as the impact of UAM on waiting time, on which these recommendations are based. As no clear criteria could be determined to differentiate potentially harmful from harmless HLA antibodies, the general recommendation is to assign all HLA against which plausible antibodies are found as UAM. There is, however, a need for individualized solutions for highly immunized patients. These revised recommendations provide a list of aspects that need to be considered when assigning UAM to enable a fair and comprehensible procedure and to harmonize risk stratification prior to kidney transplantation between transplant centers.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIBODY-MEDIATED REJECTION; DONOR-SPECIFIC ANTIBODIES; HUMAN-LEUKOCYTE ANTIGENS; DP-SPECIFIC ANTIBODIES; IMMUNOLOGICAL RISK; CLINICAL-RELEVANCE; RENAL-TRANSPLANT; BEAD ASSAYS; CROSS-MATCH; C1Q; HLA antibodies; immunological risk; kidney transplantation; unacceptable antigen mismatches; waiting time |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 07 Sep 2023 12:37 |
| Last Modified: | 07 Sep 2023 12:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58586 |
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