Gueresir, Erdem and Lampmann, Tim and Bele, Sylvia and Czabanka, Marcus and Czorlich, Patrick and Gempt, Jens and Goldbrunner, Roland and Hurth, Helene and Hermann, Elvis and Jabbarli, Ramazan and Krauthausen, Marius and Koenig, Ralph and Lindner, Dirk and Malinova, Vesna and Meixensberger, Jurgen and Mielke, Dorothee and Nemeth, Robert and Oppong, Marvin Darkwah and Pala, Andrej and Prinz, Vincent and Rashidi, Ali and Roder, Constantin and Sandalcioglu, Ibrahim Erol and Sauvigny, Thomas and Schebesch, Karl-Michael and Timmer, Marco and Vajkoczy, Peter and Wessels, Lars and Wild, Florian and Wilhelm, Christoph and Wostrack, Maria and Vatter, Hartmut and Coch, Christoph (2023) Fight INflammation to Improve outcome after aneurysmal Subarachnoid HEmorRhage (FINISHER) trial: Study protocol for a randomized controlled trial. INTERNATIONAL JOURNAL OF STROKE, 18 (2): 1747493022. pp. 242-247. ISSN 1747-4930, 1747-4949
Full text not available from this repository. (Request a copy)Abstract
Rationale: Aneurysmal subarachnoid hemorrhage (SAH) has high morbidity and mortality. While the primary injury results from the initial bleeding cannot currently be influenced, secondary injury through vasospasm and delayed cerebral ischemia worsens outcome and might be a target for interventions to improve outcome. To date, beside the aneurysm treatment to prevent re-bleeding and the administration of oral nimodipine, there is no therapy available, so novel treatment concepts are needed. Evidence suggests that inflammation contributes to delayed cerebral ischemia and poor outcome in SAH. Some studies suggest a beneficial effect of anti-inflammatory glucocorticoids, but there are no data from randomized controlled trials examining the efficacy of glucocorticoids. Therefore, current guidelines do not recommend the use of glucocorticoids in SAH. Aim: The Fight INflammation to Improve outcome after aneurysmal Subarachnoid HEmorRhage (FINISHER) trial aims to determine whether dexamethasone improves outcome in a clinically relevant endpoint in SAH patients. Methods and design: FINISHER is a multicenter, prospective, randomized, double-blinded, placebo-controlled clinical phase III trial which is testing the outcome and safety of anti-inflammatory treatment with dexamethasone in SAH patients. Sample size estimates: In all, 334 patients will be randomized to either dexamethasone or placebo within 48 h after SAH. The dexamethasone dose is 8 mg tds for days 1-7 and then 8 mg od for days 8-21. Study outcome: The primary outcome is the modified Rankin Scale (mRS) at 6 months, which is dichotomized to favorable (mRS 0-3) versus unfavorable (mRS 4-6). Discussion: The results of this study will provide the first phase III evidence as to whether dexamethasone improves outcome in SAH.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Dexamethasone; glucocorticoid; aneurysm; subarachnoid hemorrhage; inflammation; clinical trail |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Mar 2024 13:46 |
| Last Modified: | 05 Mar 2024 13:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58618 |
Actions (login required)
 |
View Item |
