Passweg, Jakob R. and Baldomero, Helen and Chabannon, Christian and Corbacioglu, Selim and de la Camara, Rafael and Dolstra, Harry and Glass, Bertram and Greco, Raffaella and Mohty, Mohamad and Neven, Benedicte and de Latour, Regis Peffault and Peric, Zinaida and Snowden, John A. and Yakoub-Agha, Ibrahim and Sureda, Anna and Kroeger, Nicolaus (2022) Impact of the SARS-CoV-2 pandemic on hematopoietic cell transplantation and cellular therapies in Europe 2020: a report from the EBMT activity survey. BONE MARROW TRANSPLANTATION, 57 (5). pp. 742-752. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
In 2020, 45,364 HCT in 41,016 patients, 18,796 (41%) allogeneic and 26,568 (59%) autologous in 690 centers were reported. Changes observed were as follows: total number of HCT -6.5%, allogeneic HCT -5.1%, autologous HCT -7.5%, and were more pronounced in non-malignant disorders for allogeneic HCT and in autoimmune disease for autologous HCT. Main indications were myeloid malignancies 10,441 (25%), lymphoid malignancies 26,120 (64%) and non-malignant disorders 2532 (6%). A continued growth in CAR-T cellular therapies to 1874 (+65%) patients in 2020 was observed. In allogeneic HCT, the use of haploidentical donors increased while use of unrelated and sibling donors decreased. Cord blood HCT increased by 11.7% for the first time since 2012. There was a significant increase in the use of non-myeloablative but a drop in myeloablative conditioning and in use of marrow as stem cell source. We interpreted these changes as being due to the SARS-CoV-2 pandemic starting early in 2020 in Europe and provided additional data reflecting the varying impact of the pandemic across selected countries and larger cities. The transplant community confronted with the pandemic challenge, continued in providing patients access to treatment. This annual report of the EBMT reflects current activities useful for health care planning.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | T-CELLS; BLOOD; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Jan 2024 15:04 |
| Last Modified: | 29 Jan 2024 15:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58621 |
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