Abdellatif, Ahmed A. H. and Abdelfattah, Ahmed and Bouazzaoui, Abdellatif and Osman, Shaaban K. K. and Al-Moraya, Issa Saad and Showail, Abdulaziz M. Saleh and Alsharidah, Mansour and Aboelela, Ashraf and Al Rugaie, Osamah and Faris, Tarek M. M. and Tawfeek, Hesham M. M. (2022) Silver Nanoparticles Stabilized by Poly (Vinyl Pyrrolidone) with Potential Anticancer Activity towards Prostate Cancer. BIOINORGANIC CHEMISTRY AND APPLICATIONS, 2022: 6181448. ISSN 1565-3633, 1687-479X
Full text not available from this repository. (Request a copy)Abstract
Tumor necrosis factor (TNF-alpha) and inflammatory cytokine (IL-6) play a vital role in various cellular incidents such as the proliferation and death of cells during carcinogenesis. Hence, regulation of these biomarkers could be a promising tool for controlling tumor progression using nanoformulations. Silver nanoparticles-poly (vinyl pyrrolidone) (AgNPs-PVP) were prepared using the reduction of silver nitrate and stabilized with PVP. They are characterized through yield percentage, UV-VIS, FT-IR, size, charge, and morphology. The obtained AgNPs were tested for anticancer activity against prostate cancer (PC 3) and human skin fibroblast (HFS) cell lines. Moreover, biomarker-based confirmations like TNF-alpha and IL-6 were estimated. The synthesized AgNPs-PVP were stable, spherical in shape, with particle sizes of 122.33 +/- 17.61 nm, a polydispersity index of 0.49 +/- 0.07, and a negative surface charge of -19.23 +/- 0.61 mV. In vitro cytotoxicity testing showed the AgNPs-PVP exhibited antiproliferation properties in PC3 in a dose-dependent manner. In addition, when compared to control cells, AgNPs-PVP has lower TNF-alpha with a significant value (*p < 0.05); the value reached 16.84 +/- 0.71 pg/ml versus 20.81 +/- 0.44 pg/ml, respectively. In addition, HSF cells showed a high level of reduction (***p < 0.001) in IL-6 production. This study suggested that AgNPs-PVP could be a possible therapeutic agent for human prostate cancer and anti-IL-6 in cancerous and noncancerous cells. Further studies will be performed to investigate the effect of AgNPs-PVP in different types of cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; GOLD NANOPARTICLES; SOMATOSTATIN RECEPTORS; CHONDROITIN SULFATE; FACTOR-ALPHA; EXPRESSION; INTERLEUKIN-6; DELIVERY; DIFFERENTIATION; NANOTECHNOLOGY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2024 06:42 |
| Last Modified: | 01 Feb 2024 06:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58631 |
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