Jaeschke, Lina and Becher, Matthias and Velasquez, Ilais Moreno and Ahrens, Wolfgang and Bachle, Christina and Baurecht, Hansjorg and Fricke, Julia and Greiser, Karin Halina and Gunther, Kathrin and Heier, Margit and Karch, Andre and Kluttig, Alexander and Krist, Lilian and Leitzmann, Michael and Michels, Karin and Mikolajczyk, Rafael and Peters, Annette and Schipf, Sabine and Volzke, Henry and Pischon, Tobias and Becher, Heiko (2022) The bias from heaping on risk estimation: effect of age at diagnosis of hypertension on risk of subsequent cardiovascular comorbidities. ANNALS OF EPIDEMIOLOGY, 74. pp. 84-96. ISSN 1047-2797, 1873-2585
Full text not available from this repository. (Request a copy)Abstract
Purpose: To investigate (1) the bias in effect estimation due to heaping or digit preference, (2) the as-sociation between age at hypertension diagnosis and risk of cardiovascular comorbidities, and (3) the influence of heaping on risk estimates.Methods: We performed a simulation study with various scenarios, binary outcome, and normal or log-normal distributed covariables. We calculated mean logistic coefficients under the original and heaped data and their relative deviation. The association of age at hypertension diagnosis and risk of >= 1 cardio-vascular comorbidity was investigated using logistic regression among 50,858 participants in the NAKO Gesundheitsstudie (German National Cohort) who reported such diagnosis. We assessed the proportion of heaped observations and to what extent heaping may have influenced risk estimates.Results: Based on the simulation study and assuming 50% of observations in the variable of interest to be heaped, relative bias was < 6%. In NAKO, a 5-year younger age at hypertension diagnosis was asso-ciated with a 15% increased risk of having >= 1 cardiovascular comorbidity. Observed heaping in age at hypertension diagnosis was 12.6%, and bias of the risk estimate was 0.14%.Conclusions: Bias in effect estimation due to heaping is low in most common scenarios. Younger age at hypertension diagnosis is associated with a higher risk of cardiovascular comorbidities.(c) 2022 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BLOOD-PRESSURE; METABOLIC DISEASES; COHORT; ONSET; Heaping; Digit preference; Simulation study; Effect estimates; Epidemiologic study; Hypertension; Cardiovascular comorbidities |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2023 07:46 |
| Last Modified: | 14 Dec 2023 07:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58657 |
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