Yaici, Remi and Roth, Mathias and Juergens, Lukas and Al Nawaiseh, Sami and Burkhard, Dick and Besgen, Volker and Fuest, Matthias and Girbardt, Christian and Hampel, Ulrike and Heichel, Jens and Heiligenhaus, Arnd and Herwig-Carl, Martina C. and Kakkassery, Vinodh and Kontopoulou, Kalliopi and Löffler, Karin U. and Maier, Philip Christian and Nölle, Bernhard and Pach, Johanna and Paul, Sebastian and Pleyer, Uwe and Pöllmann, Michael and Saeger, Mark and Schmidt, Enno and Siebelmann, Sebastian and Sokolenko, Ekatarina and Strudel, Lisa and Stübiger, Nicole and Tarhan, Melih and Theuersbacher, Johanna and van Oterendorp, Christian and Walker, Marten and Wiecha, Carolin and Wykrota, Agata Anna and Geerling, Gerd (2023) On the Current Care Situation and Treatment of Ocular Mucous Membrane Pemphigoid in Germany. KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE, 240 (09). pp. 1077-1083. ISSN 0023-2165, 1439-3999
Full text not available from this repository. (Request a copy)Abstract
Background Ocular involvement in mucous membrane pemphigoid (MMP) is relatively rare, with a prevalence of 25 cases per million population, equating to approx. 2,100 patients throughout Germany. Diagnosis can be difficult - especially in cases of isolated ocular involvement - and treatment can be complex and lengthy. Immunosuppressants or immunomodulatory drugs are often used. Due to the complexity of diagnosis and treatment, MMP patients are usually referred to specialized centers. The aim of this project was to evaluate the current care situation of patients with ocular MMP in Germany. Methods A paper-based survey was designed and sent to all university eye clinics and other specialized centers in Germany in April 2020. The survey asked about the existence of a specialized outpatient service, the total annual number of patients with MMP, the annual number of newly diagnosed patients, any interdisciplinary collaboration for diagnostic or therapeutic purposes, as well as the local and systemic therapy used. Results Of a total of 44 clinics, 28 (64%) responded, reporting a total average of 27 +/- 42 (0 - 200) patients and 3.6 +/- 2.2 (0 - 10) new cases per year. This corresponds to a total of 741 patients. Only nine (32%) of the responding clinics offer specialized MMP clinics. 93% of the centers collaborate with the local dermatology department. 79% perform serological and histological diagnostics in-house. About half of the centers (n = 16) apply a standardized treatment regime. Systemic glucocorticoids (66.7%) are most commonly used, followed by mycophenolate mofetil and dapsone (57.1%), rituximab (33.3%), azathioprine and cyclophosphamide (28.6%), as well as methotrexate (19.0%). The least frequently used treatment is intravenous immunoglobulin (14.3%). Conclusion This survey of German ophthalmology departments obtained data from about one third of the estimated total cohort of all patients with MMP in Germany. These are presumed to be exclusively patients with at least one ocular involvement. The complex care of these patients is usually provided in collaboration with a dermatologist and with the use of systemic anti-inflammatory medication. Currently, an ophthalmological MMP register is being established to better record the epidemiology and care situation of this rare disease in Germany and to improve it in the long term. Background Ocular involvement in mucous membrane pemphigoid (MMP) is relatively rare, with a prevalence of 25 cases per million population, equating to approx. 2,100 patients throughout Germany. Diagnosis can be difficult - especially in cases of isolated ocular involvement - and treatment can be complex and lengthy. Immunosuppressants or immunomodulatory drugs are often used. Due to the complexity of diagnosis and treatment, MMP patients are usually referred to specialized centers. The aim of this project was to evaluate the current care situation of patients with ocular MMP in Germany. Methods A paper-based survey was designed and sent to all university eye clinics and other specialized centers in Germany in April 2020. The survey asked about the existence of a specialized outpatient service, the total annual number of patients with MMP, the annual number of newly diagnosed patients, any interdisciplinary collaboration for diagnostic or therapeutic purposes, as well as the local and systemic therapy used. Results Of a total of 44 clinics, 28 (64%) responded, reporting a total average of 27 +/- 42 (0 - 200) patients and 3.6 +/- 2.2 (0 - 10) new cases per year. This corresponds to a total of 741 patients. Only nine (32%) of the responding clinics offer specialized MMP clinics. 93% of the centers collaborate with the local dermatology department. 79% perform serological and histological diagnostics in-house. About half of the centers (n = 16) apply a standardized treatment regime. Systemic glucocorticoids (66.7%) are most commonly used, followed by mycophenolate mofetil and dapsone (57.1%), rituximab (33.3%), azathioprine and cyclophosphamide (28.6%), as well as methotrexate (19.0%). The least frequently used treatment is intravenous immunoglobulin (14.3%). Conclusion This survey of German ophthalmology departments obtained data from about one third of the estimated total cohort of all patients with MMP in Germany. These are presumed to be exclusively patients with at least one ocular involvement. The complex care of these patients is usually provided in collaboration with a dermatologist and with the use of systemic anti-inflammatory medication. Currently, an ophthalmological MMP register is being established to better record the epidemiology and care situation of this rare disease in Germany and to improve it in the long term.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CICATRISING CONJUNCTIVITIS; RITUXIMAB; KERATOPROSTHESIS; THERAPY; survey; mucous membrane pemphigoid; immunosuppression; register; Germany; therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Petra Gürster |
| Date Deposited: | 05 Sep 2023 11:07 |
| Last Modified: | 05 Sep 2023 11:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58721 |
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