McDowell, Colleen M. and Kizhatil, Krishnakumar and Elliott, Michael H. and Overby, Darryl R. and Van Batenburg-Sherwood, Joseph and Millar, J. Cameron and Kuehn, Markus H. and Zode, Gulab and Acott, Ted S. and Anderson, Michael G. and Bhattacharya, Sanjoy K. and Bertrand, Jacques A. and Borras, Terete and Bovenkamp, Diane E. and Cheng, Lin and Danias, John and De Ieso, Michael Lucio and Du, Yiqin and Faralli, Jennifer A. and Fuchshofer, Rudolf and Ganapathy, Preethi S. and Gong, Haiyan and Herberg, Samuel and Hernandez, Humberto and Humphries, Peter and John, Simon W. M. and Kaufman, Paul L. and Keller, Kate E. and Kelley, Mary J. and Kelly, Ruth A. and Krizaj, David and Kumar, Ajay and Leonard, Brian C. and Lieberman, Raquel L. and Liton, Paloma and Liu, Yutao and Liu, Katy C. and Lopez, Navita N. and Mao, Weiming and Mavlyutov, Timur and McDonnell, Fiona and McLellan, Gillian J. and Mzyk, Philip and Nartey, Andrews and Pasquale, Louis R. and Patel, Gaurang C. and Pattabiraman, Padmanabhan P. and Peters, Donna M. and Raghunathan, Vijaykrishna and Rao, Ponugoti Vasantha and Rayana, Naga and Raychaudhuri, Urmimala and Reina-Torres, Ester and Ren, Ruiyi and Rhee, Douglas and Chowdhury, Uttio Roy and Samples, John R. and Samples, E. Griffen and Sharif, Najam and Schuman, Joel S. and Sheffield, Val C. and Stevenson, Cooper H. and Soundararajan, Avinash and Subramanian, Preeti and Sugali, Chenna Kesavulu and Sun, Yang and Toris, Carol B. and Torrejon, Karen Y. and Vahabikashi, Amir and Vranka, Janice A. and Wang, Ting and Willoughby, Colin E. and Xin, Chen and Yun, Hongmin and Zhang, Hao F. and Fautsch, Michael P. and Tamm, Ernst R. and Clark, Abbot F. and Ethier, C. Ross and Stamer, W. Daniel (2022) Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 63 (2): 12. ISSN 0146-0404, 1552-5783
Full text not available from this repository. (Request a copy)Abstract
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OPEN-ANGLE GLAUCOMA; TRABECULAR MESHWORK CELLS; OPTIC-NERVE DAMAGE; INTRAOCULAR-PRESSURE; EXTRACELLULAR-MATRIX; HYDROGEN-SULFIDE; RESCUES GLAUCOMA; HUMAN EYES; SYMPATHETIC NEUROTRANSMISSION; NONINVASIVE DETERMINATION; mouse model; conventional outflow; glaucoma; intraocular pressure; ocular hypertension; outflow facility |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2023 07:50 |
| Last Modified: | 13 Dec 2023 07:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58725 |
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