Stefan, Norbert and Sippel, Katrin and Heni, Martin and Fritsche, Andreas and Wagner, Robert and Jakob, Carolin E. M. and Preissl, Hubert and von Werder, Alexander and Khodamoradi, Yascha and Borgmann, Stefan and Ruethrich, Maria Madeleine and Hanses, Frank and Haselberger, Martina and Piepel, Christiane and Hower, Martin and vom Dahl, Jurgen and Wille, Kai and Roemmele, Christoph and Vehreschild, Janne and Stecher, Melanie and Solimena, Michele and Roden, Michael and Schuermann, Annette and Gallwitz, Baptist and de Angelis, Martin Hrabe and Ludwig, David S. and Schulze, Matthias B. and Jensen, Bjoern Erik Ole and Birkenfeld, Andreas L. (2022) Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry. FRONTIERS IN MEDICINE, 9: 875430. ISSN , 2296-858X
Full text not available from this repository. (Request a copy)Abstract
Advanced age, followed by male sex, by far poses the greatest risk for severe COVID-19. An unresolved question is the extent to which modifiable comorbidities increase the risk of COVID-19-related mortality among younger patients, in whom COVID-19-related hospitalization strongly increased in 2021. A total of 3,163 patients with SARS-COV-2 diagnosis in the Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort were studied. LEOSS is a European non-interventional multi-center cohort study established in March 2020 to investigate the epidemiology and clinical course of SARS-CoV-2 infection. Data from hospitalized patients and those who received ambulatory care, with a positive SARS-CoV-2 test, were included in the study. An additive effect of obesity, diabetes and hypertension on the risk of mortality was observed, which was particularly strong in young and middle-aged patients. Compared to young and middle-aged (18-55 years) patients without obesity, diabetes and hypertension (non-obese and metabolically healthy; n = 593), young and middle-aged adult patients with all three risk parameters (obese and metabolically unhealthy; n = 31) had a similar adjusted increased risk of mortality [OR 7.42 (95% CI 1.55-27.3)] as older (56-75 years) non-obese and metabolically healthy patients [n = 339; OR 8.21 (95% CI 4.10-18.3)]. Furthermore, increased CRP levels explained part of the elevated risk of COVID-19-related mortality with age, specifically in the absence of obesity and impaired metabolic health. In conclusion, the modifiable risk factors obesity, diabetes and hypertension increase the risk of COVID-19-related mortality in young and middle-aged patients to the level of risk observed in advanced age.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONAVIRUS; HOSPITALIZATION; ASSOCIATIONS; ENGLAND; obesity; diabetes; hypertension; impaired metabolic health; mortality; COVID-19 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Notfallambulanz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2023 07:22 |
| Last Modified: | 13 Dec 2023 07:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58742 |
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