Schons, Maximilian and Pilgram, Lisa and Reese, Jens-Peter and Stecher, Melanie and Anton, Gabriele and Appel, Katharina S. and Bahmer, Thomas and Bartschke, Alexander and Bellinghausen, Carla and Bernemann, Inga and Brechtel, Markus and Brinkmann, Folke and Bruenn, Clara and Dhillon, Christine and Fiessler, Cornelia and Geisler, Ramsia and Hamelmann, Eckard and Hansch, Stefan and Hanses, Frank and Hanss, Sabine and Herold, Susanne and Heyder, Ralf and Hopff, Sina Marie and Horn, Anna and Jakob, Carolin and Keil, Thomas and Khodamoradi, Yascha and Kohls, Mirjam and Kraus, Monika and Krefting, Dagmar and Kunze, Sonja and Kurth, Florian and Lieb, Wolfgang and Lippert, Lena Johanna and Lorbeer, Roberto and Maetzler, Corina and Miljukov, Olga and Nauck, Matthias and Pape, Daniel and Puntmann, Valentina and Reinke, Lennart and Roemmele, Christoph and Rudolph, Stefanie and Sass, Julian and Schaefer, Christian and Schaller, Jens and Schattschneider, Mario and Scheer, Christian and Scherer, Margarete and Schmidt, Sein and Schmidt, Julia and Seibel, Kristina and Stahl, Dana and Steinbeis, Fridolin and Stoerk, Stefan and Tauchert, Maike and Tebbe, Johannes Josef and Thibeault, Charlotte and Toepfner, Nicole and Ungethuem, Kathrin and Vadasz, Istvan and Valentin, Heike and Wiedmann, Silke and Zoller, Thomas and Nagel, Eike and Krawczak, Michael and von Kalle, Christof and Illig, Thomas and Schreiber, Stefan and Witzenrath, Martin and Heuschmann, Peter and Vehreschild, Jorg Janne (2022) The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 37 (8): s10654-022. pp. 849-870. ISSN 0393-2990, 1573-7284
Full text not available from this repository. (Request a copy)Abstract
The German government initiated the Network University Medicine (NUM) in early 2020 to improve national research activities on the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic. To this end, 36 German Academic Medical Centers started to collaborate on 13 projects, with the largest being the National Pandemic Cohort Network (NAPKON). The NAPKON's goal is creating the most comprehensive Coronavirus Disease 2019 (COVID-19) cohort in Germany. Within NAPKON, adult and pediatric patients are observed in three complementary cohort platforms (Cross-Sectoral, High-Resolution and Population-Based) from the initial infection until up to three years of follow-up. Study procedures comprise comprehensive clinical and imaging diagnostics, quality-of-life assessment, patient-reported outcomes and biosampling. The three cohort platforms build on four infrastructure core units (Interaction, Biosampling, Epidemiology, and Integration) and collaborations with NUM projects. Key components of the data capture, regulatory, and data privacy are based on the German Centre for Cardiovascular Research. By April 01, 2022, 34 university and 40 non-university hospitals have enrolled 5298 patients with local data quality reviews performed on 4727 (89%). 47% were female, the median age was 52 (IQR 36-62-) and 50 pediatric cases were included. 44% of patients were hospitalized, 15% admitted to an intensive care unit, and 12% of patients deceased while enrolled. 8845 visits with biosampling in 4349 patients were conducted by April 03, 2022. In this overview article, we summarize NAPKON's design, relevant milestones including first study population characteristics, and outline the potential of NAPKON for German and international research activities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COVID-19; COVID-19; SARS-CoV-2; Prospective national cohort; Longitudinal study; Epidemiology; Cross-sectoral; Population-based |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Krankenhaushygiene und Infektiologie Medicine > Notfallambulanz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2023 07:18 |
| Last Modified: | 13 Dec 2023 07:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58788 |
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