Hawchar, Fatime and Tomescu, Dana and Traeger, Karl and Joskowiak, Dominik and Kogelmann., Klaus and Soukup., Jens and Friesecke, Singrun. and Jacob, David and Gummert, Jan and Faltlhauser, Andreas and Aucella, Filippo and van Tellingen, Martijn and Malbrain, Manu L. N. G. and Bogdanski, Ralph and Weiss, Guenter and Herbrich, Andreas and Utzolino, Stefan and Nierhaus, Axel and Baumann, Andreas and Hartjes, Andreas and Henzler, Dietrich and Grigoryev, Evgeny and Fritz, Harald and Bach, Friedhelm and Schroeder, Stefan and Weyland, Andreas and Gottschaldt, Udo and Menzel, Matthias and Zachariae, Olivier and Novak, Radovan and Berden, Jernej and Haake, Hendrik and Quintel, Michael and Kloesel, Stephan and Kortgen, Andreas and Stecher, Stephanie and Torti, Patricia and Nestler, Frieder and Nitsch, Markus and Olboeter, Detlef and Muck, Philip and Findeisen, Michael and Bitzinger, Diane and Krassler, Jens and Benad, Martin and Schott, Martin and Schumacher, Ulrike and Molnar, Zsolt and Brunkhorst, Frank Martin (2022) Hemoadsorption in the critically ill-Final results of the International CytoSorb Registry. PLOS ONE, 17 (10): e0274315. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
The aim of the current paper is to summarize the results of the International CytoSorb Registry. Data were collected on patients of the intensive care unit. The primary endpoint was actual in-hospital mortality compared to the mortality predicted by APACHE II score. The main secondary endpoints were SOFA scores, inflammatory biomarkers and overall evaluation of the general condition. 1434 patients were enrolled. Indications for hemoadsorption were sepsis/septic shock (N = 936); cardiac surgery perioperatively (N = 172); cardiac surgery postoperatively (N = 67) and "other" reasons (N = 259). APACHE-II-predicted mortality was 62.0 +/- 24.8%, whereas observed hospital mortality was 50.1%. Overall SOFA scores did not change but cardiovascular and pulmonary SOFA scores decreased by 0.4 [-0.5;-0.3] and -0.2 [-0.3;-0.2] points, respectively. Serum procalcitonin and C-reactive protein levels showed significant reduction: -15.4 [-19.6;-11.17] ng/mL; -17,52 [-70;44] mg/L, respectively. In the septic cohort PCT and IL-6 also showed significant reduction: -18.2 [-23.6;-12.8] ng/mL; -2.6 [-3.0;-2.2] pg/mL, respectively. Evaluation of the overall effect: minimal improvement (22%), much improvement (22%) and very much improvement (10%), no change observed (30%) and deterioration (4%). There was no significant difference in the primary outcome of mortality, but there were improvements in cardiovascular and pulmonary SOFA scores and a reduction in PCT, CRP and IL-6 levels.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SEPTIC SHOCK; CARDIOPULMONARY BYPASS; SEPSIS; DEFINITIONS; SURGERY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Sep 2023 10:22 |
| Last Modified: | 19 Sep 2023 10:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58822 |
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