Feltgen, Nicolas and Ach, Thomas and Ziemssen, Focke and Quante, Carolin Sophie and Gross, Oliver and Abdin, Alaa Din and Aisenbrey, Sabine and Bartram, Martin C. and Blum, Marcus and Brockmann, Claudia and Dithmar, Stefan and Friedrichs, Wilko and Guthoff, Rainer and Hattenbach, Lars-Olof and Herrlinger, Klaus R. and Kaskel-Paul, Susanne and Khoramnia, Ramin and Klaas, Julian E. and Krohne, Tim U. and Lommatzsch, Albrecht and Lueken, Sabine and Maier, Mathias and Nassri, Lina and Nguyen-Dang, Thien A. and Radeck, Viola and Rau, Saskia and Roider, Johann and Sandner, Dirk and Schmalenberger, Laura and Schmidtmann, Irene and Schubert, Florian and Siegel, Helena and Spitzer, Martin S. and Stahl, Andreas and Stingl, Julia and Treumer, Felix and Viestenz, Arne and Wachtlin, Joachim and Wolf, Armin and Zimmermann, Julian and Schargus, Marc and Schuster, Alexander K. (2022) Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study. JOURNAL OF CLINICAL MEDICINE, 11 (17): 5101. ISSN , 2077-0383
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Background: To investigate whether vaccination against SARS-CoV-2 is associated with the onset of retinal vascular occlusive disease (RVOD). Methods: In this multicentre study, data from patients with central and branch retinal vein occlusion (CRVO and BRVO), central and branch retinal artery occlusion (CRAO and BRAO), and anterior ischaemic optic neuropathy (AION) were retrospectively collected during a 2-month index period (1 June-31 July 2021) according to a defined protocol. The relation to any previous vaccination was documented for the consecutive case series. Numbers of RVOD and COVID-19 vaccination were investigated in a case-by-case analysis. A case-control study using age- and sex-matched controls from the general population (study participants from the Gutenberg Health Study) and an adjusted conditional logistic regression analysis was conducted. Results: Four hundred and twenty-one subjects presenting during the index period (61 days) were enrolled: one hundred and twenty-one patients with CRVO, seventy-five with BRVO, fifty-six with CRAO, sixty-five with BRAO, and one hundred and four with AION. Three hundred and thirty-two (78.9%) patients had been vaccinated before the onset of RVOD. The vaccines given were BNT162b2/BioNTech/Pfizer (n = 221), followed by ChadOx1/AstraZeneca (n = 57), mRNA-1273/Moderna (n = 21), and Ad26.COV2.S/Johnson & Johnson (n = 11; unknown n = 22). Our case-control analysis integrating population-based data from the GHS yielded no evidence of an increased risk after COVID-19 vaccination (OR = 0.93; 95% CI: 0.60-1.45, p = 0.75) in connection with a vaccination within a 4-week window. Conclusions: To date, there has been no evidence of any association between SARS-CoV-2 vaccination and a higher RVOD risk.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RISK-FACTORS; ARTERY; retinal vein occlusion; retinal artery occlusion; anterior ischaemic optic neuropathy; infection; vaccination; SARS-CoV-2; COVID-19 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Sep 2023 12:55 |
| Last Modified: | 19 Sep 2023 12:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58824 |
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