Winkler, Thomas W. and Rasheed, Humaira and Teumer, Alexander and Gorski, Mathias and Rowan, Bryce X. and Stanzick, Kira J. and Thomas, Laurent F. and Tin, Adrienne and Hoppmann, Anselm and Chu, Audrey Y. and Tayo, Bamidele and Thio, Chris H. L. and Cusi, Daniele and Chai, Jin-Fang and Sieber, Karsten B. and Horn, Katrin and Li, Man and Scholz, Markus and Cocca, Massimiliano and Wuttke, Matthias and van der Most, Peter J. and Yang, Qiong and Ghasemi, Sahar and Nutile, Teresa and Li, Yong and Pontali, Giulia and Guenther, Felix and Dehghan, Abbas and Correa, Adolfo and Parsa, Afshin and Feresin, Agnese and de Vries, Aiko P. J. and Zonderman, Alan B. and Smith, Albert and Oldehinkel, Albertine J. and De Grandi, Alessandro and Rosenkranz, Alexander R. and Franke, Andre and Teren, Andrej and Metspalu, Andres and Hicks, Andrew A. and Morris, Andrew P. and Toenjes, Anke and Morgan, Anna and Podgornaia, Anna and Peters, Annette and Koerner, Antje and Mahajan, Anubha and Campbell, Archie and Freedman, Barry and Spedicati, Beatrice and Ponte, Belen and Schoettker, Ben and Brumpton, Ben and Banas, Bernhard and Kraemer, Bernhard K. and Jung, Bettina and Asvold, Bjorn Olav and Smith, Blair H. and Ning, Boting and Penninx, Brenda W. J. H. and Vanderwerff, Brett R. and Psaty, Bruce M. and Kammerer, Candace M. and Langefeld, Carl D. and Hayward, Caroline and Spracklen, Cassandra N. and Robinson-Cohen, Cassianne and Hartman, Catharina A. and Lindgren, Cecilia M. and Wang, Chaolong and Sabanayagam, Charumathi and Heng, Chew-Kiat and Lanzani, Chiara and Khor, Chiea-Chuen and Cheng, Ching-Yu and Fuchsberger, Christian and Gieger, Christian and Shaffer, Christian M. and Schulz, Christina-Alexandra and Willer, Cristen J. and Chasman, Daniel and Gudbjartsson, Daniel F. and Ruggiero, Daniela and Toniolo, Daniela and Czamara, Darina and Porteous, David J. and Waterworth, Dawn M. and Mascalzoni, Deborah and Mook-Kanamori, Dennis O. and Reilly, Dermot F. and Daw, E. Warwick and Hofer, Edith and Boerwinkle, Eric and Salvi, Erika and Bottinger, Erwin P. and Tai, E-Shyong and Catamo, Eulalia and Rizzi, Federica and Guo, Feng and Rivadeneira, Fernando and Guilianini, Franco and Sveinbjornsson, Gardar and Ehret, Georg and Waeber, Gerard and Biino, Ginevra and Girotto, Giorgia and Pistis, Giorgio and Nadkarni, Girish N. and Delgado, Graciela E. and Montgomery, Grant W. and Snieder, Harold and Campbell, Harry and White, Harvey D. and Gao, He and Stringham, Heather M. and Schmidt, Helena and Li, Hengtong and Brenner, Hermann and Holm, Hilma and Kirsten, Holgen and Kramer, Holly and Rudan, Igor and Nolte, Ilja M. and Tzoulaki, Ioanna and Olafsson, Isleifur and Martins, Jade and Cook, James P. and Wilson, James F. and Halbritter, Jan and Felix, Janine F. and Divers, Jasmin and Kooner, Jaspal S. and Lee, Jeannette Jen-Mai and O'Connell, Jeffrey and Rotter, Jerome and Liu, Jianjun and Xu, Jie and Thiery, Joachim and Arnlov, Johan and Kuusisto, Johanna and Jakobsdottir, Johanna and Tremblay, Johanne and Chambers, John C. and Whitfield, John B. and Gaziano, John M. and Marten, Jonathan and Coresh, Josef and Jonas, Jost B. and Mychaleckyj, Josyf C. and Christensen, Kaare and Eckardt, Kai-Uwe and Mohlke, Karen L. and Endlich, Karlhans and Dittrich, Katalin and Ryan, Kathleen A. and Rice, Kenneth M. and Taylor, Kent D. and Ho, Kevin and Nikus, Kjell and Matsuda, Koichi and Strauch, Konstantin and Miliku, Kozeta and Hveem, Kristian and Lind, Lars and Wallentin, Lars and Yerges-Armstrong, Laura M. and Raffield, Laura M. and Phillips, Lawrence S. and Launer, Lenore J. and Lyytikainen, Leo-Pekka and Lange, Leslie A. and Citterio, Lorena and Klaric, Lucija and Ikram, M. Arfan and Ising, Marcus and Kleber, Marcus E. and Francescatto, Margherita and Concas, Maria Pina and Ciullo, Marina and Piratsu, Mario and Orho-Melander, Marju and Laakso, Markku and Loeffler, Markus and Perola, Markus and de Borst, Martin H. and Gogele, Martin and La Bianca, Martina and Lukas, Mary Ann and Feitosa, Mary F. and Biggs, Mary L. and Wojczynski, Mary K. and Kavousi, Maryam and Kanai, Masahiro and Akiyama, Masato and Yasuda, Masayuki and Nauck, Matthias and Waldenberger, Melanie and Chee, Miao-Li and Chee, Miao-Ling and Boehnke, Michael and Preuss, Michael H. and Stumvoll, Michael and Province, Michael A. and Evans, Michele K. and O'Donoghue, Michelle L. and Kubo, Michiaki and Kahonen, Mika and Kastarinen, Mika and Nalls, Mike A. and Kuokkanen, Mikko and Ghanbari, Mohsen and Bochud, Murielle and Josyula, Navya Shilpa and Martin, Nicholas G. and Tan, Nicholas Y. Q. and Palmer, Nicholette D. and Pirastu, Nicola and Schupf, Nicole and Verweij, Niek and Hutri-Kahonen, Nina and Mononen, Nina and Bansal, Nisha and Devuyst, Olivier and Melander, Olle and Raitakari, Olli T. and Polasek, Ozren and Manunta, Paolo and Gasparini, Paolo and Mishra, Pashupati P. and Sulem, Patrick and Magnusson, Patrik K. E. and Elliott, Paul and Ridker, Paul M. and Hamet, Pavel and Svensson, Per O. and Joshi, Peter K. and Kovacs, Peter and Pramstaller, Peter P. and Rossing, Peter and Vollenweider, Peter and van der Harst, Pim and Dorajoo, Rajkumar and Sim, Ralene Z. H. and Burkhardt, Ralph and Tao, Ran and Noordam, Raymond and Magi, Reedik and Schmidt, Reinhold and de Mutsert, Renee and Rueedi, Rico and van Dam, Rob M. and Carroll, Robert J. and Gansevoort, Ron T. and Loos, Ruth J. F. and Felicita, Sala Cinzia and Sedaghat, Sanaz and Padmanabhan, Sandosh and Freitag-Wolf, Sandra and Pendergrass, Sarah A. and Graham, Sarah E. and Gordon, Scott D. and Hwang, Shih-Jen and Kerr, Shona M. and Vaccargiu, Simona and Patil, Snehal B. and Hallan, Stein and Bakker, Stephan J. L. and Lim, Su-Chi and Lucae, Susanne and Vogelezang, Suzanne and Bergmann, Sven and Corre, Tanguy and Ahluwalia, Tarunveer S. and Lehtimaki, Terho and Boutin, Thibaud S. and Meitinger, Thomas and Wong, Tien-Yin and Bergler, Tobias and Rabelink, Ton J. and Esko, Tonu and Haller, Toomas and Thorsteinsdottir, Unnur and Voelker, Uwe and Foo, Valencia Hui Xian and Salomaa, Veikko and Vitart, Veronique and Giedraitis, Vilmantas and Gudnason, Vilmundur and Jaddoe, Vincent W. V. and Huang, Wei and Zhang, Weihua and Wei, Wen Bin and Kiess, Wieland and Marz, Winfried and Koenig, Wolfgang and Lieb, Wolfgang and Gao, Xin and Sim, Xueling and Wang, Ya Xing and Friedlander, Yechiel and Tham, Yih-Chung and Kamatani, Yoichiro and Okada, Yukinori and Milaneschi, Yuri and Yu, Zhi and Stark, Klaus J. and Stefansson, Kari and Boeger, Carsten A. and Hung, Adriana M. and Kronenberg, Florian and Koettgen, Anna and Pattaro, Cristian and Heid, Iris M. (2022) Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. COMMUNICATIONS BIOLOGY, 5 (1): 580. ISSN , 2399-3642
Full text not available from this repository. (Request a copy)Abstract
A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease. Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n(DM) = 178,691, n(noDM) = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; ENVIRONMENT INTERACTION; QUALITY-CONTROL; METAANALYSIS; LOCI; JOINT; EFFICIENT; SMOKING; DISEASE; EXPRESSION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Sep 2023 07:02 |
| Last Modified: | 19 Sep 2023 07:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58844 |
Actions (login required)
 |
View Item |
