Evershed, Richard P. and Smith, George Davey and Roffet-Salque, Melanie and Timpson, Adrian and Diekmann, Yoan and Lyon, Matthew S. and Cramp, Lucy J. E. and Casanova, Emmanuelle and Smyth, Jessica and Whelton, Helen L. and Dunne, Julie and Brychova, Veronika and Soberl, Lucija and Gerbault, Pascale and Gillis, Rosalind E. and Heyd, Volker and Johnson, Emily and Kendall, Iain and Manning, Katie and Marciniak, Arkadiusz and Outram, Alan K. and Vigne, Jean-Denis and Shennan, Stephen and Bevan, Andrew and Colledge, Sue and Allason-Jones, Lyndsay and Amkreutz, Luc and Anders, Alexandra and Arbogast, Rose-Marie and Balasescu, Adrian and Banffy, Eszter and Barclay, Alistair and Behrens, Anja and Bogucki, Peter and Alonso, Angel Carrancho and Carretero, Jose Miguel and Cavanagh, Nigel and Classen, Erich and Giraldo, Hipolito Collado and Conrad, Matthias and Csengeri, Piroska and Czerniak, Lech and Debiec, Maciej and Denaire, Anthony and Domboroczki, Laszlo and Donald, Christina and Ebert, Julia and Evans, Christopher and Frances-Negro, Marta and Gronenborn, Detlef and Haack, Fabian and Halle, Matthias and Hamon, Caroline and Hulshoff, Roman and Ilett, Michael and Iriarte, Eneko and Jakucs, Janos and Jeunesse, Christian and Johnson, Melanie and Jones, Andy M. and Karul, Necmi and Kiosak, Dmytro and Kotova, Nadezhda and Krause, Rudiger and Kretschmer, Saskia and Kruger, Marta and Lefranc, Philippe and Lelong, Olivia and Lenneis, Eva and Logvin, Andrey and Luth, Friedrich and Marton, Tibor and Marley, Jane and Mortimer, Richard and Oosterbeek, Luiz and Oross, Krisztian and Pavuk, Juraj and Pechtl, Joachim and Petrequin, Pierre and Pollard, Joshua and Pollard, Richard and Powlesland, Dominic and Pyzel, Joanna and Raczky, Pal and Richardson, Andrew and Rowe, Peter and Rowland, Stephen and Rowlandson, Ian and Saile, Thomas and Sebok, Katalin and Schier, Wolfram and Schmalfuss, Germo and Sharapova, Svetlana and Sharp, Helen and Sheridan, Alison and Shevnina, Irina and Sobkowiak-Tabaka, Iwona and Stadler, Peter and Stauble, Harald and Stobbe, Astrid and Stojanovski, Darko and Tasic, Nenad and van Wijk, Ivo and Vostrovska, Ivana and Vukovic, Jasna and Wolfram, Sabine and Zeeb-Lanz, Andrea and Thomas, Mark G. (2022) Dairying, diseases and the evolution of lactase persistence in Europe. NATURE, 608 (7922). 336-+. ISSN 0028-0836, 1476-4687
Full text not available from this repository. (Request a copy)Abstract
In European and many African, Middle Eastern and southern Asian populations, lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over the past 10,000 years(1). Although the selection of LP and the consumption of prehistoric milk must be linked, considerable uncertainty remains concerning their spatiotemporal configuration and specific interactions(2,3). Here we provide detailed distributions of milk exploitation across Europe over the past 9,000 years using around 7,000 pottery fat residues from more than 550 archaeological sites. European milk use was widespread from the Neolithic period onwards but varied spatially and temporally in intensity. Notably, LP selection varying with levels of prehistoric milk exploitation is no better at explaining LP allele frequency trajectoriesthan uniform selection since the Neolithic period. In the UK Biobank(4,5) cohort of 500,000 contemporary Europeans, LP genotype was only weakly associated with milk consumption and did not show consistent associations with improved fitness or health indicators. This suggests that other reasons for the beneficial effects of LP should be considered for its rapid frequency increase. We propose that lactase non-persistent individuals consumed milk when it became available but, under conditions of famine and/or increased pathogen exposure, this was disadvantageous, driving LP selection in prehistoric Europe. Comparison of model likelihoods indicates that population fluctuations, settlement density and wild animal exploitation-proxies for these drivers-provide better explanations of LP selection than the extent of milk exploitation. These findings offer new perspectives on prehistoric milk exploitation and LP evolution.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ORGANIC RESIDUE ANALYSIS; ADULT LACTOSE-INTOLERANCE; ANCIENT HUMAN GENOMES; CORDED WARE CULTURE; GROWTH-FACTOR-I; LIPID RESIDUE; POTTERY USE; ANIMAL EXPLOITATION; MILK CONSUMPTION; NEOLITHIC SITE; |
| Subjects: | 900 History & geography > 930 History of the ancient world |
| Divisions: | Philosophy, Art History, History, and Humanities > Institut für Geschichte > Vor- und Frühgeschichte - Prof. Dr. Thomas Saile |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Sep 2023 13:25 |
| Last Modified: | 19 Sep 2023 13:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58850 |
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