Zuckermann, Andreas and Schulz, Uwe and Deuse, Tobias and Ruhpawar, Arjang and Schmitto, Jan D. and Beiras-Fernandez, Andres and Hirt, Stephan and Schweiger, Martin and Kopp-Fernandes, Laurenz and Barten, Markus J. (2015) Thymoglobulin induction in heart transplantation: patient selection and implications for maintenance immunosuppression. TRANSPLANT INTERNATIONAL, 28 (3). pp. 259-269. ISSN 0934-0874, 1432-2277
Full text not available from this repository. (Request a copy)Abstract
Clinical data relating to rabbit antithymocyte globulin (rATG) induction in heart transplantation are far less extensive than for other immunosuppressants, or indeed for rATG in other indications. This was highlighted by the low grade of evidence and the lack of detailed recommendations for prescribing rATG in the International Society for Heart and Lung Transplantation (ISHLT) guidelines. The heart transplant population includes an increasing frequency of patients on mechanical circulatory support (MCS), often with ongoing infection and/or presensitization, who are at high immunological risk but also vulnerable to infectious complications. The number of patients with renal impairment is also growing due to lengthening waiting times, intensifying the need for strategies that minimize calcineurin inhibitor (CNI) toxicity. Additionally, the importance of donorspecific antibodies (DSA) in predicting graft failure is influencing immunosuppressive regimens. In light of these developments, and in view of the lack of evidence-based prescribing criteria, experts from Germany, Austria, and Switzerland convened to identify indications for rATG induction in heart transplantation and to develop an algorithm for its use based on patient characteristics.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RABBIT ANTITHYMOCYTE GLOBULIN; POSTTRANSPLANTATION LYMPHOPROLIFERATIVE DISORDER; POSTOPERATIVE RENAL DYSFUNCTION; SOLID-ORGAN TRANSPLANTATION; VENTRICULAR ASSIST DEVICES; ANTI-THYRNOCYTE GLOBULIN; FOCUS THEME AGE; CARDIAC TRANSPLANTATION; LUNG TRANSPLANTATION; INTERNATIONAL SOCIETY; antithymocyte globulin; heart transplantation; rabbit antithymocyte globulin; Thymoglobulin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Aug 2020 09:16 |
| Last Modified: | 14 Aug 2020 09:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5891 |
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