Hense, Katharina and Deuter, Daniel and Greenlee, Mark W. and Wendl, Christina and Schmidt, Nils Ole and Stroszczynski, Christian and Doenitz, Christian and Ott, Christian and Rosengarth, Katharina (2023) Analysis of Functional Neuroplastic Changes in the Cortical Language System in Relation to Different Growth Patterns of Glioblastoma. BRAIN SCIENCES, 13 (6): 867. ISSN , 2076-3425
Full text not available from this repository. (Request a copy)Abstract
The interpretation of fMRI data in glioblastoma (GB) is challenging as these tumors exhibit specific hemodynamic processes which, together with malignancy, tumor volume and proximity to eloquent cortex areas, may lead to misinterpretations of fMRI signals. The aim of this study was to investigate if different radiologically defined GB tumor growth patterns may also influence the fMRI signal, activation pattern and functional connectivity differently. Sixty-four patients with left-hemispheric glioblastoma were included and stratified according to their radiologically defined tumor growth pattern into groups with a uniform (U-TGP) or diffuse tumor growth pattern (D-TGP). Task-based fMRI data were analyzed using SPM12 with the marsbar, LI and CONN toolboxes. The percent signal change and the laterality index were analyzed, as well as functional connectivity between 23 selected ROIs. Comparisons of both patient groups showed only minor non-significant differences, indicating that the tumor growth pattern is not a relevant influencing factor for fMRI signal. In addition to these results, signal reductions were found in areas that were not affected by the tumor underlining that a GB is not a localized but rather a systemic disease affecting the entire brain.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BRAIN-TUMORS; FMRI ACTIVATION; MOTOR CORTEX; CONNECTIVITY; MRI; GRADE; PROGRESSION; PROGNOSIS; ADJACENT; SURVIVAL; glioblastoma; heterogeneity; brain tumor; functional magnetic resonance imaging; blood oxygenation level dependent imaging; task-based functional connectivity; preoperative mapping; preoperative noninvasive imaging |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Röntgendiagnostik Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Mar 2024 14:39 |
| Last Modified: | 07 Mar 2024 14:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58938 |
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