Zhou, Jordi Yang (2023) Innate immunity and early liver inflammation. FRONTIERS IN IMMUNOLOGY, 14: 1175147. ISSN 1664-3224
Full text not available from this repository. (Request a copy)Abstract
The innate system constitutes a first-line defence mechanism against pathogens. 80% of the blood supply entering the human liver arrives from the splanchnic circulation through the portal vein, so it is constantly exposed to immunologically active substances and pathogens from the gastrointestinal tract. Rapid neutralization of pathogens and toxins is an essential function of the liver, but so too is avoidance of harmful and unnecessary immune reactions. This delicate balance of reactivity and tolerance is orchestrated by a diverse repertoire of hepatic immune cells. In particular, the human liver is enriched in many innate immune cell subsets, including Kupffer cells (KCs), innate lymphoid cells (ILCs) like Natural Killer (NK) cells and ILC-like unconventional T cells - namely Natural Killer T cells (NKT), gamma delta T cells and Mucosal-associated Invariant T cells (MAIT). These cells reside in the liver in a memory-effector state, so they respond quickly to trigger appropriate responses. The contribution of aberrant innate immunity to inflammatory liver diseases is now being better understood. In particular, we are beginning to understand how specific innate immune subsets trigger chronic liver inflammation, which ultimately results in hepatic fibrosis. In this review, we consider the roles of specific innate immune cell subsets in early inflammation in human liver disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | KILLER T-CELLS; II NKT CELLS; ISCHEMIA-REPERFUSION INJURY; INDUCED HEPATIC STEATOSIS; B-VIRUS REPLICATION; MAIT CELLS; KUPFFER CELLS; LYMPHOCYTE SUBPOPULATIONS; INSULIN-RESISTANCE; ACTIVATION; Inflammation; Innate immnuity; Hepatitis (general); NK cells; MAIT cell; Gd T cell; NKT (natural killer T) cell; kupffer cell (KC) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Feb 2024 11:12 |
| Last Modified: | 21 Feb 2024 11:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58943 |
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