Larivera, Simone and Neumeier, Julia and Meister, Gunter (2023) Post-transcriptional gene silencing in a dynamic RNP world. BIOLOGICAL CHEMISTRY, 404 (11-12). pp. 1051-1067. ISSN 1431-6730, 1437-4315
Full text not available from this repository. (Request a copy)Abstract
MicroRNA (miRNA)-guided gene silencing is a key regulatory process in various organisms and linked to many human diseases. MiRNAs are processed from precursor molecules and associate with Argonaute proteins to repress the expression of complementary target mRNAs. Excellent work by numerous labs has contributed to a detailed understanding of the mechanisms of miRNA function. However, miRNA effects have mostly been analyzed and viewed as isolated events and their natural environment as part of complex RNA-protein particles (RNPs) is often neglected. RNA binding proteins (RBPs) regulate key enzymes of the miRNA processing machinery and furthermore RBPs or readers of RNA modifications may modulate miRNA activity on mRNAs. Such proteins may function similarly to miRNAs and add their own contributions to the overall expression level of a particular gene. Therefore, post-transcriptional gene regulation might be more the sum of individual regulatory events and should be viewed as part of a dynamic and complex RNP world.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CCR4-NOT DEADENYLASE COMPLEX; HUMAN ARGONAUTE PROTEINS; NUCLEAR IMPORT RECEPTOR; MESSENGER-RNA; BINDING PROTEIN; TRANSLATIONAL REPRESSION; PRIMARY MICRORNAS; STRUCTURAL BASIS; GW182 PROTEINS; CRYSTAL-STRUCTURE; microRNA; RBP; m6A; gene silencing; deadenylation |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Feb 2024 05:46 |
| Last Modified: | 22 Feb 2024 05:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58959 |
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