Sag, Sabine Julia Maria and Mueller, Stephanie and Wallner, Stefan and Strack, Christina and Hubauer, Ute and Mohr, Margareta and Zeller, Judith and Loew, Thomas and Rehli, Michael and Wimmer, Julia and Zimmermann, Martina Erika and Maier, Lars Siegfried and Fischer, Marcus and Baessler, Andrea (2023) A multilocus genetic risk score for obesity: Association with BMI and metabolic alterations in a cohort with severe obesity. MEDICINE, 102 (32). ISSN 0025-7974, 1536-5964
Full text not available from this repository. (Request a copy)Abstract
Genome wide association studies have identified numerous single nucleotide polymorphisms (SNPs) associated with obesity, yet effect sizes of individual SNPs are small. Therefore, the aim of our study was to investigate whether a genetic risk score (GRS) comprising risk alleles of SNPs identified in the GIANT consortium meta-analyses shows association with body mass index (BMI) and other BMI related metabolic alterations in a cohort with an extreme phenotype. Genotyping of 93 SNPs was performed in 314 obese individuals (mean BMI 40.5 & PLUSMN; 7.8 kg/m(2), aged 45 & PLUSMN; 12 years), participating in a standardized weight reduction program, and in 74 lean controls (mean BMI 24.6 & PLUSMN; 3.3 kg/m(2), aged 41.7 & PLUSMN; 13.4 years). Allele numbers of all 93 SNPs were added to a GRS. Anthropometric parameters, parameters of glucose/insulin and lipid metabolism were assessed standardized after a 12 hours fast. GRS was significantly different between controls and obese individuals (unweighted GRS: 86.6 vs 89.0, P = .002; weighted GRS: 84.9 vs 88.3, P = .005). Furthermore, linear regression analysis showed significant associations of GRS with BMI (P < .0001), weight (P = .0005), waist circumference (P = .0039), fat mass (P < .0001) and epicardial fat thickness (P = .0032), yet with small effect sizes (r(2) < 0.06). In conclusion, in our study GRS could differentiate between extreme obese and lean individuals, and was associated with BMI and its related traits, yet with small effect sizes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BODY-MASS INDEX; WEIGHT-REDUCTION; INSIGHTS; LOCI; genetic risk score; obesity; single nucleotide polymorphism; weight |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Psychosomatische Medizin Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Mar 2024 15:47 |
| Last Modified: | 07 Mar 2024 15:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58978 |
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