Menon, Rohit and Neumann, Inga D. (2023) Detection, processing and reinforcement of social cues: regulation by the oxytocin system. NATURE REVIEWS NEUROSCIENCE, 24. pp. 761-777. ISSN 1471-003X, 1471-0048
Full text not available from this repository. (Request a copy)Abstract
Many social behaviours are evolutionarily conserved and are essential for the healthy development of an individual. The neuropeptide oxytocin (OXT) is crucial for the fine-tuned regulation of social interactions in mammals. The advent and application of state-of-the-art methodological approaches that allow the activity of neuronal circuits involving OXT to be monitored and functionally manipulated in laboratory mammals have deepened our understanding of the roles of OXT in these behaviours. In this Review, we discuss how OXT promotes the sensory detection and evaluation of social cues, the subsequent approach and display of social behaviour, and the rewarding consequences of social interactions in selected reproductive and non-reproductive social behaviours. Social stressors - such as social isolation, exposure to social defeat or social trauma, and partner loss - are often paralleled by maladaptations of the OXT system, and restoring OXT system functioning can reinstate socio-emotional allostasis. Thus, the OXT system acts as a dynamic mediator of appropriate behavioural adaptations to environmental challenges by enhancing and reinforcing social salience and buffering social stress. The neuropeptide oxytocin has a vital role in many mammalian social behaviours. Here, Menon and Neumann provide a comprehensive review of the rodent neuronal circuits in which oxytocin acts to regulate the processing of social cues in order to reinforce reproductive and non-reproductive social behaviours.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GAMMA-AMINOBUTYRIC-ACID; RECEPTOR GENE OXTR; NUCLEUS-ACCUMBENS; INTRANASAL OXYTOCIN; OLFACTORY-BULB; MATERNAL-BEHAVIOR; BRAIN OXYTOCIN; PARAVENTRICULAR NUCLEUS; HYPOTHALAMIC NEURONS; ARGININE-VASOPRESSIN |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Feb 2024 07:03 |
| Last Modified: | 22 Feb 2024 07:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58987 |
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