Riebel, Marco and von Pappenheim, Benedikt and Kanig, Carolina and Nothdurfter, Caroline and Wetter, Thomas C. and Rupprecht, Rainer and Schwarzbach, Jens (2023) GABAergic Effects of Etifoxine and Alprazolam Assessed by Double Pulse TMS. PHARMACOPSYCHIATRY, 56 (04). pp. 154-161. ISSN 0176-3679, 1439-0795
Full text not available from this repository. (Request a copy)Abstract
Introduction There is a need for novel anxiolytics with improved side effect profiles compared to benzodiazepines. A promising candidate with alternative pharmacodynamics is the translocator protein ligand, etifoxine. Methods To get further insight into its mechanisms of action and side effects compared to the benzodiazepine alprazolam, we performed a double-blind, placebo-controlled, repeated-measures study in 36 healthy male subjects. Participants were examined for trait anxiety and side effects and underwent repeated transcranial magnetic stimulation (TMS) assessments, including motor evoked potentials (MEP), short intracortical inhibition (SICI), intracortical facilitation (ICF), and cortical silent period (CSP). Results We observed attenuation of MEPs by alprazolam but not by etifoxine. SICI was not significantly affected by alprazolam or etifoxine. However, the response pattern indicated a lowered SICI threshold after the administration of etifoxine and alprazolam compared to the placebo. ICF and CSP were influenced by neither medication. Alprazolam led to higher sedation and subjective impairment of concentration compared to etifoxine. Individual anxiety trait scores did not affect TMS parameters. Discussion This study indicated a favorable side effect profile of etifoxine in healthy volunteers. Moreover, it revealed differential GABA-related effects on neuromuscular function by means of TMS. The side effects and TMS profile of etifoxine are compatible with the involvement of neurosteroidogenesis and a predominant alpha 3 subunit modulation compared to alprazolam.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN MOTOR CORTEX; INTRACORTICAL INHIBITION; FACILITATION; LORAZEPAM; RECEPTOR; ANXIETY; EXCITABILITY; ANXIOLYTICS; DISORDER; TMS; TSPO; benzodiazepines; etifoxine; GABA |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Mar 2024 16:06 |
| Last Modified: | 07 Mar 2024 16:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58990 |
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