Weber, Markus and von Kunow, Frederik and Hillmann, Axel (2023) Marginal resection as a potential curative treatment option of infantile fibrosarcoma with good response after chemotherapy: A case report of an ETV6-NTRK3 positive infantile fibrosacroma of the distal tibia. MEDICINE, 102 (27). ISSN 0025-7974, 1536-5964
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Rationale:The infantile fibrosarcoma (IFS) is a non-rhabdomyosarcoma soft tissue sarcoma with locally aggressive properties. State of the art therapy consists of neoadjuvant chemotherapy followed by wide resection according to the criteria of the musculoskeletal tumor society. Diagnoses:An ETV6-NTRK3 positive IFS of the distal tibia in a 21-months old child showed good response to chemotherapy. Interventions:Due to refusal of amputation marginal resection completing the margins with a high speed drill and filling the space with bone cement was performed. Outcomes:At latest follow-up 10 years after surgery, no recurrence was observed. Lessons:An individual therapy for surgical treatment of IIFS is recommended. This comprises marginal resection in instead of the golden standard "wide resection" in selected cases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONGENITAL FIBROSARCOMA; SPONTANEOUS REGRESSION; GENE FUSION; TUMORS; infantile fibrosarcoma; marginal resection; surgery; therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Mar 2024 17:17 |
| Last Modified: | 07 Mar 2024 17:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59022 |
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