Kaufmann, Christina and Zech, Nina and Brandt, Florian and Hilker, Michael and Debl, Kurt and Creutzenberg, Marcus and Zeman, Florian and Graf, Bernhard M. M. and Sinner, Barbara (2023) Intraoperative suggestions to prevent postoperative delirium in patients undergoing transaortic valvular replacement: a randomized placebo-controlled trial. AGING CLINICAL AND EXPERIMENTAL RESEARCH, 35 (9). pp. 1865-1872. ISSN 1594-0667, 1720-8319
Full text not available from this repository. (Request a copy)Abstract
BackgroundPostoperative delirium (POD) is a serious complication following anaesthesia and surgery and significantly influences postoperative outcome especially in the elderly population. Intraoperative music and positive suggestions influence postoperative outcomes by attenuating analgesic demand and increasing patient satisfaction.AimsHere, we examined the effect of intraoperative music and positive suggestions on the development of POD in aged patients undergoing transcatheter aortic valve replacement (TAVR) procedure under general anaesthesia.MethodsFor this randomized placebo-controlled study, eligible patients without cognitive deficit, indicated by a MMSE < 10 points, were anesthetized using remifentanil and sevoflurane. Anaesthetic depth was guide with bispectral index. An audiotape with positive suggestions was applied from a MP3 player via headphones. POD, pain and PONV was assessed. CAM-ICU and Nu-DESC were done twice daily for the first 5 days.ResultsOf 140 patients 118 patients could be analysed (57 male, 80.6 & PLUSMN; 5.1 years). POD was diagnosed in 16 patients (12.7%). POD was significantly more often observed in male (12, 21.1%) than in female (4, 6.6%, p = 0.02) and in patients with a low MMSE (23.6 & PLUSMN; 4.5 vs. 26.8 & PLUSMN; 2.8, p = 0.001). Anaesthetic depth did not influence the incidence of POD. Intraoperative music and suggestions did not affect the rate of POD, pain, analgesic requirement or PONV.DiscussionIn patients undergoing TAVR male sex and low MMSE scoring are associated with an increase in POD.ConclusionsIntraoperative music and positive suggestions do not influence the incidence of POD in this patient group.Study registrationDRKS: 00024444, start of registration: 4.02.202, final registration: 17.09.2021
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENERAL-ANESTHESIA; ELECTROENCEPHALOGRAM; AWARENESS; RESPONSES; Intraoperative suggestions; Transcatheter aortic valve replacement; Postoperative delirium |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Feb 2024 09:43 |
| Last Modified: | 22 Feb 2024 09:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59059 |
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