Kleber, Julia and Zhou, Jordi Yang and Weber, Florian and Bitterer, Florian and Hauer, Patricia and Kupke, Paul and Kronenberg, Katharina and Geissler, Edward K. and Schlitt, Hans J. and Hornung, Matthias and Hutchinson, James A. and Werner, Jens M. (2023) Immune profile of patients with peritoneal carcinomatosis selected for CRS-HIPEC therapy. CANCER IMMUNOLOGY IMMUNOTHERAPY, 72 (11). pp. 3867-3873. ISSN 0340-7004, 1432-0851
Full text not available from this repository. (Request a copy)Abstract
Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment option for peritoneal carcinomatosis (PC) from colorectal cancer (CRC), which is otherwise a terminal stage of disease. Nevertheless, survival outcomes are only marginally superior to other treatments. This fact highlights the need for better strategies to control intra-abdominal disease recurrence after CRS-HIPEC, including the complementary use of immunotherapies. The aim of this study was therefore to investigate the immune phenotype of T cells in patients with PC. Fifty three patients with CRC (34 patients with PC and 19 patients without PC) were enrolled in a prospective study (clinicaltrials.gov: NCT04108936). Peripheral blood and omental fat were collected to isolate peripheral blood mononuclear cells (PBMCs) and adipose tissue mononuclear cells (ATMCs). These cells were analysed by flow cytometry using a panel focused upon T cell memory differentiation and exhaustion markers. We found a more naive profile for CD8(+)T cells in peripheral blood and intra-abdominal fat of PC patients compared to comparator group (CG) patients. Furthermore, there was an over-representation of CD4(+)T cells expressing inhibitory receptors in adipose tissue of PC patients, but not in blood. Our description of intraperitoneal T cell subsets gives us a better understanding of how peritoneal carcinomatosis shapes local immune responses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; CYTOREDUCTIVE SURGERY; ANTIBODY CATUMAXOMAB; OPEN-LABEL; MULTICENTER; Peritoneal carcinomatosis; Colorectal cancer; CRS; HIPEC; Immunotherapy; Memory T cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2024 09:31 |
| Last Modified: | 08 Mar 2024 09:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59067 |
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