Maldonado, Rodrigo and Laengst, Gernot (2023) The chromatin - triple helix connection. BIOLOGICAL CHEMISTRY, 404 (11-12). pp. 1037-1049. ISSN 1431-6730, 1437-4315
Full text not available from this repository.Abstract
Mammalian genomes are extensively transcribed, producing a large number of coding and non-coding transcripts. A large fraction of the nuclear RNAs is physically associated with chromatin, functioning in gene activation and silencing, shaping higher-order genome organisation, such as involvement in long-range enhancer-promoter interactions, transcription hubs, heterochromatin, nuclear bodies and phase transitions. Different mechanisms allow the tethering of these chromatin-associated RNAs (caRNA) to chromosomes, including RNA binding proteins, the RNA polymerases and R-loops. In this review, we focus on the sequence-specific targeting of RNA to DNA by forming triple helical structures and describe its interplay with chromatin. It turns out that nucleosome positioning at triple helix target sites and the nucleosome itself are essential factors in determining the formation and stability of triple helices. The histone H3-tail plays a critical role in triple helix stabilisation, and the role of its epigenetic modifications in this process is discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LONG NONCODING RNAS; OLIGONUCLEOTIDE TARGET SEQUENCES; NUCLEOSOME CORE PARTICLES; C+CENTER-DOT-GC; T-CENTER-DOT; FORMING OLIGONUCLEOTIDES; DNA TRIPLEX; COMPLEX-FORMATION; INTERPHASE CHROMOSOMES; STRANDED DNA; chromatin; chromatin-associated RNA; lncRNA; nucleosome; RNA-DNA triple helix |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Feb 2024 07:23 |
| Last Modified: | 27 Feb 2024 07:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59077 |
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