Dueker, Jonas and Ghosh, Indrajit and Koenig, Burkhard (2023) Sequential One-Pot (Het)arene Thioetherification and Amination with Nickel and Visible Light. ACS CATALYSIS, 13 (20). pp. 13618-13625. ISSN 2155-5435
Full text not available from this repository. (Request a copy)Abstract
The development of predictable methods to increase molecular complexity is of paramount importance in modern organic chemistry, especially in the context of synthesizing multifunctionalized (het)arenes in active pharmaceutical ingredients (APIs) and materials. While considerable progress has been made using various protocols, sequential one-pot carbon-heteroatom cross-coupling reactions remain challenging. Herein, we report reaction conditions under adaptive dynamic homogeneous catalysis (AD-HoC) that offer a facile introduction of functional groups onto (het)aromatic scaffolds, resulting in significantly increased molecular complexity and controlled construction of a diverse library of molecules. Moreover, the photoredox reaction conditions employed in AD-HoC introduce a layer of versatility, as the conditions offer distinct selectivity in reactions involving pyrimidines. Manipulating the selectivity is of tremendous value in designing targeted synthesis routes for specific molecules and APIs. The simplicity and predictability of AD-HoC reaction conditions, along with the benefits of photoredox chemistry, make this approach an appealing choice for researchers aiming to create complex molecules.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CROSS-COUPLING REACTIONS; CATALYZED C-S; HALOGENATED NITROGEN; BOND FORMATION; VINYL HALIDES; ARYL; PHOTOREDOX; HETEROARYL; LIGAND; REGIOSELECTIVITY; AD-HoC; photoredox catalysis; visible light; nickel; cross-coupling; difunctionalization; (het)arene |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Feb 2024 10:00 |
| Last Modified: | 27 Feb 2024 10:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59093 |
Actions (login required)
 |
View Item |
