Eichberger, Jonas and Froschhammer, Daniel and Schulz, Daniela and Scholz, Konstantin J. and Federlin, Marianne and Ebensberger, Helga and Reichert, Torsten E. and Ettl, Tobias and Bauer, Richard J. (2023) BMSC-HNC Interaction: Exploring Effects on Bone Integrity and Head and Neck Cancer Progression. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (19): 14417. ISSN 1661-6596, 1422-0067
Full text not available from this repository. (Request a copy)Abstract
In recent research, the tumor microenvironment has been shown to attract mesenchymal stromal cells (MSCs), which is of particular interest due to its implications for cancer progression. The study focused on understanding the interaction between bone marrow-derived MSCs (BMSCs) and head and neck cancer (HNC) cells. This interaction was found to activate specific markers, notably the osteogenic marker alkaline phosphatase and the oncogene Runx2. These activations corresponded with the release of collagenase enzymes, MMP9 and MMP2. To gain insights into bone resorption related to this interaction, bovine bone slices were used, supporting the growth of "heterogeneous spheroids" that contained both BMSCs and HNC cells. Through scanning electron microscopy and energy-dispersive X-ray (EDX) analysis, it was observed that these mixed spheroids were linked to a notable increase in bone degradation and collagen fiber exposure, more so than spheroids of just BMSCs or HNC cells. Furthermore, the EDX results highlighted increased nitrogen content on bone surfaces with these mixed clusters. Overall, the findings underscore the significant role of BMSCs in tumor growth, emphasizing the need for further exploration in potential cancer treatment strategies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESENCHYMAL STEM-CELLS; CARCINOMA-ASSOCIATED FIBROBLASTS; METASTASIS; INVASION; MARROW; MMP-9; MATRIX-METALLOPROTEINASE-9; GROWTH; head and neck cancer; bone marrow-derived stromal cells; collagenase enzymes; MMP-1; MMP-9 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2024 09:56 |
| Last Modified: | 08 Mar 2024 09:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59105 |
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