Brandl, Caroline and Zimmermann, Martina E. and Herold, Janina M. and Helbig, Horst and Stark, Klaus J. and Heid, Iris M. (2023) Photostress Recovery Time as a Potential Predictive Biomarker for Age-Related Macular Degeneration. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 12 (2): 15. ISSN 2164-2591
Full text not available from this repository. (Request a copy)Abstract
Purpose: The purpose of this study was to assess recovery time following photostress and its association with age-related macular degeneration (AMD) cross-sectionally and longitudinally in an elderly population-based cohort. Methods: We analyzed photostress recovery time (PRT) and AMD in >1800 AugUR study participants aged 70+ years. On color fundus images from baseline and 3-year follow-up, presence of AMD was graded manually ( Three Continent AMD Consortium Severity Scale). Visual acuity (VA) was assessed via Early Treatment Diabetic Retinopathy Study (ETDRS) charts. After a 30-second bleaching of the macular region via direct ophthalmoscope, PRT was measured as the seconds to regain VA. Results: First, we analyzed 1208 AugUR participants cross-sectionally (288 with early AMD, and 78 with late AMD). Prolonged PRT was associated with early and late AMD versus no AMD (median PRT = 119.5, 198.0 versus 80.0 seconds, respectively; logistic regression odds ratio [OR] = 1.109-1.165 per 10 seconds, P values < 0.0001). Sensitivity analyses using alternativemodels or restricting to participants after cataract surgery revealed similar ORs. Second, the association was confirmed in an independent cross-sectional AugUR sample (n = 486). Third, in longitudinal analysis of 233 AugUR participants without AMD, prolonged PRT was associated with incident AMD ascertained 3 years later (follow-up time = 3.2 +/- 0.2 years, OR = 1.112-1.162 per 10 seconds, P < 0.05). Overall, we demonstrate a significant association of prolonged PRT with AMD cross-sectionally and longitudinally in elderly individuals. Conclusions: Prolonged PRT might capture retinal function impairment after cell damage before early AMD is visible via color fundus imaging. Translational Relevance: Our results suggest PRT as quantitative predictive biomarker for incident AMD, making it potentially worthwhile also for clinical care.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLARE DISABILITY; MACULOPATHY; ASSOCIATION; LUTEIN; age-related macular degeneration (AMD); photostress test; photostress recovery time (PRT); biomarker; population-based study; genetic risk score (GRS) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2024 05:33 |
| Last Modified: | 28 Feb 2024 05:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59108 |
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