Bittner, Sebastian and Hehlgans, Thomas and Feuerer, Markus (2023) Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond. TRENDS IN IMMUNOLOGY, 44 (6). pp. 468-483. ISSN 1471-4906, 1471-4981
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Regulatory T (Treg) cells ensure tolerance against self-antigens, limit excessive inflammation, and support tissue repair processes. Therefore, Treg cells are cur-rently attractive candidates for the treatment of certain inflammatory diseases, autoimmune disorders, or transplant rejection. Early clinical trials have proved the safety and efficacy of certain Treg cell therapies in inflammatory diseases. We summarize recent advances in engineering Treg cells, including the concept of biosensors for inflammation. We assess Treg cell engineering possibilities for novel functional units, including Treg cell modifications influencing stability, mi-gration, and tissue adaptation. Finally, we outline perspectives of engineered Treg cells going beyond inflammatory diseases by using custom-designed re-ceptors and read-out systems, aiming to use Treg cells as in vivo diagnostic tools and drug delivery vehicles.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; VERSUS-HOST-DISEASE; TRANSCRIPTION FACTOR; SLEEPING-BEAUTY; EX-VIVO; AUTOIMMUNE ENCEPHALOMYELITIS; ADOPTIVE TRANSFER; GENE-TRANSFER; CUTTING EDGE; THERAPY |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2024 06:02 |
| Last Modified: | 28 Feb 2024 06:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59126 |
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